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Cell signaling and biological pathway in cardiovascular diseases

  • Cheong-Whan Chae
  • Yoo-Wook KwonEmail author
Review

Abstract

Currently, coronary artery disease accounts for a large proportion of deaths occurring worldwide. Damage to the heart muscle over a short period of time leads to myocardial infarction (MI). The biological mechanisms of atherosclerosis, one of the causes of MI, have been well studied. Resistin, a type of adipokine, is closely associated with intravascular level of low-density lipoprotein cholesterol and augmentation of the expression of adhesion molecules in endothelial cells. Therefore, resistin, which is highly associated with inflammation, can progress into coronary artery disease. Adenylyl cyclase associated protein 1, a binding partner of resistin, also plays an important role in inducing pro-inflammatory cytokines. The induction of these cytokines can aggravate atherosclerosis by promoting severe plaque rupture of the lesion site. Recently, drugs, such as statins that can inhibit inflammation have been extensively studied. The development of effective new drugs that can directly or indirectly block pro-inflammatory cytokines may have a great potential in the treatment of coronary artery disease in the future.

Keywords

Myocardial infarction Atherosclerosis Inflammation Resistin Form cell 

Notes

Compliance with ethical standards

Conflict of interest

All authors declared no conflict of interest.

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© The Pharmaceutical Society of Korea 2019

Authors and Affiliations

  1. 1.National Research Laboratory for Stem Cell Niche, Center for Medical InnovationSeoul National University HospitalSeoulRepublic of Korea
  2. 2.Biomedical Research InstituteSeoul National University HospitalSeoulRepublic of Korea
  3. 3.Department of MedicineSeoul National University College of MedicineSeoulRepublic of Korea

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