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Rab25 and RCP in cancer progression

  • Kyung Hwa Cho
  • Hoi Young LeeEmail author
Review

Abstract

Cancer invasion and metastasis is the crucial cause of death for most cancer patients. Endosome recycling of receptors for growth factors and adhesion molecules to the plasma membrane prevents them from degradation at the inside of the lysosome and recapitulates their functions, leading to major causativeness of cancer progression. Rab25 belongs to Rab-GTPase family and implicated in cancer progression in a context-dependent manner. Identified as a binding partner of Rab25, Rab coupling protein (RCP) augments cancer invasion and metastasis. In the present review, we document recent progress in Rab25- and RCP-induced cancer progression. In addition, we raise several questions should be answered for better understanding how endosome recycling by Rab25 and RCP influences cancer progression. Lastly, we update the potential therapeutic armaments to regulate Rab protein-induced endosome recycling for this deadly disease.

Keywords

Endosome recycling Rab protein Rab25 Rab coupling protein Cancer progression 

Abbreviations

RCP

Rab coupling protein

RTK

Receptor tyrosine kinase

EGFR

Epidermal growth factor receptor

TGF

Transforming growth factor

PI3 K

Phosphoinositide 3-kinase

GEF

Guanine nucleotide exchange factor

GAP

GTPase-activating protein

EMT

Epithelial mesenchymal transition

DNMTs

DNA methyltransferases

SIRT1

Sirtuin 1

TNBC

Triple-negative breast cancer

VEGF

Vascular endothelial growth factor

CLIC3

Intracellular channel protein 3

CLIC3

Chloride intracellular channel protein 3

Rab11-FIP1

Rab11 family of interacting proteins

RBD

Rab binding domain

NSCLC

Non-small cell lung carcinoma

ER

Estrogen receptor

PA

Phosphatidic acid

DGK-α

Diacylglycerol kinase alpha

GOF

Gain-of-function

MET

Mesenchymal–epithelial transition

WIP

WASP-interacting protein

YAP

Yes-associated protein

RabGGTase

Rab geranylgeranyl transferase

siRNAs

Small interfering RNAs

miRNA

microRNAs

Notes

Acknowledgements

This study was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology [NRF-2017R1E1A1A01074091, 2017R1A2B4007361].

Compliance with ethical standards

Conflict of interest

The authors declare no conflict interest.

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Copyright information

© The Pharmaceutical Society of Korea 2019

Authors and Affiliations

  1. 1.Department of Pharmacology, College of MedicineKonyang UniversityDaejeonRepublic of Korea

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