Peptide-based targeted therapeutics and apoptosis imaging probes for cancer therapy
Peptides have advantages over antibodies in terms of deep tissue penetration, low immunogenicity, and cost-effective production, but they have short circulation time and poor stability in vivo. Peptides have been extensively used as targeting moieties for the delivery of drug-loaded nanoparticles and function as targeted therapeutics in cancer treatment. Here, we review peptides that are exploited as targeted therapeutics in cancer therapy and apoptosis imaging probes for the monitoring of treatment responses.
KeywordsApoptosis CD44v6 Imaging PD-L1 Phage display Pro-apoptotic peptide Targeted therapeutics
This work was supported by Grants from the National Research Foundation (NRF- 2014R1A5A2009242 and NRF-2018R1A2B200837) and the Bio & Medical Technology Development Program (2017M3A9G8083382).
Compliance with ethical standards
Conflict of interest
The authors confirm that they have no conflict of interest.
- Adamczyk M, Kostka G, Palut D (1998) The role of apoptosis in cell physiology and pathology. Rocz Panstw Zakl Hig 49:415–432Google Scholar
- Kim ES, Kim JE, Patel MA, Mangraviti A, Ruzevick J, Lim M (2016) Immune checkpoint modulators: an emerging antiglioma armamentarium. J Immunol Res 2016:1–14Google Scholar
- Mai JC, Mi Z, Kim S-H, Ng B, Robbins PD (2001) A proapoptotic peptide for the treatment of solid tumors. Cancer Res 61:7709–7712Google Scholar
- Manish G, Vimukta S (2011) Targeted drug delivery system: a review. Res J Chem Sci 1:135–138Google Scholar
- Matzke-Ogi A, Jannasch K, Shatirishvili M, Fuchs B, Chiblak S, Morton J, Tawk B, Lindner T, Sansom O, Alves F, Warth A, Schwager C, Mier W, Kleeff J, Ponta H, Abdollahi A, Orian-Rousseau V (2016) Inhibition of tumor growth and metastasis in pancreatic cancer models by interference with CD44v6 signaling. Gastroenterology 150:513–525CrossRefGoogle Scholar
- Radermacher KA, Boutry S, Laurent S, Elst LV, Mahieu I, Bouzin C, Magat J, Gregoire V, Feron O, Muller RN, Jordan BF, Gallez B (2010) Iron oxide particles covered with hexapeptides targeted at phosphatidylserine as MR biomarkers of tumor cell death. Contrast Media Mol Imaging 5:258–267CrossRefGoogle Scholar
- Smolarczyk R, Cichoń T, Graja K, Hucz J, Sochanik A, Szala S (2006) Antitumor effect of RGD-4C-GG-D (KLAKLAK) 2 peptide in mouse B16 (F10) melanoma model. Acta Biochim Pol 53:801–805Google Scholar
- Stauder R, Eisterer W, Thaler J, Gunthert U (1995) CD44 variant isoforms in non-Hodgkin’s lymphoma: a new independent prognostic factor. Blood 85:2885–2899Google Scholar
- Wang JL, Su WY, Lin YW, Xiong H, Chen YX, Xu J, Fang JY (2017) CD44v6 overexpression related to metastasis and poor prognosis of colorectal cancer: a meta-analysis. Oncotarget 8:12866–12876Google Scholar