Archives of Pharmacal Research

, Volume 41, Issue 7, pp 743–752 | Cite as

Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans

  • Eun Byeol Lee
  • Jun Hyeong Kim
  • Yeong Jee Kim
  • Yun Jeong Noh
  • Su Jin Kim
  • In Hyun Hwang
  • Dae Keun KimEmail author
Research Article


Aging is a key risk factor for many diseases, understanding the mechanism of which is becoming more important for drug development given the fast-growing aging population. In the course of our continued efforts to discover anti-aging natural products, the active constituent 6-shogaol was isolated from Zingiber officinale Roscoe. The chemical structure of 6-shogaol was identified by comparison of its NMR data with literature values. The lifespan-extending effect of 6-shogaol was observed in a dose-dependent manner in Caenorhabditis elegans that has been widely used as a model organism for human aging studies. Mechanism of such action was investigated using C. elegans models, suggesting that 6-shogaol is capable of increasing stress tolerances via enzyme induction. The proposed mechanism was further supported by observation of the increase in SOD and HSP expressions upon treatment with 6-shogaol in transgenic strains of C. elegans which contain GFP-based reporters. In addition, the mechanism was elaborated by confirming that the effect observed for 6-shogaol is independent from other aging-related factors that are known to affect the aging process of C. elegans.


Aging 6-Shogaol Zingiber officinale Roscoe Caenorhabditis elegans Anti-aging natural products Lifespan-extending effect 



This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (2017R1D1A3B03032146).


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Copyright information

© The Pharmaceutical Society of Korea 2018

Authors and Affiliations

  • Eun Byeol Lee
    • 1
    • 2
  • Jun Hyeong Kim
    • 1
  • Yeong Jee Kim
    • 1
  • Yun Jeong Noh
    • 1
  • Su Jin Kim
    • 1
  • In Hyun Hwang
    • 1
  • Dae Keun Kim
    • 1
    Email author
  1. 1.College of PharmacyWoosuk UniversityJeonjuRepublic of Korea
  2. 2.Department of Agro-food ResourcesRural Development AdministrationWanjuRepublic of Korea

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