Chemical constituents from Viburnum fordiae Hance and their anti-inflammatory and antioxidant activities

Research Article
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Abstract

Three new neolignans, fordianoles A-C (1–3), characterized as (7S,8R)-4-hydroxy-3,3′,5′-trimethoxy-8′,9′-dinor-8,4′-oxyneolignan-7,7′,9-triol, (7R,8R)-4-hydroxy-3,3′,5′-trimethoxy-8′,9′-dinor-8,4′-oxyneolignan-7,7′,9-triol, and (7R,8R)-4-hydroxy-3,3′,5′-trimethoxy-8,4′-oxyneolignan-7,9,9′-triol-7′-one, together with an unusual γ-lactone, 3-(3,4-dihydroxyphenyl)-4-pentanolide (4), and twenty-five known compounds (529) were isolated from the aerial parts of Viburnum fordiae Hance. Their structures including absolute configurations were determined by spectroscopic and chemical methods. Among them, compounds 6, 7, 11–15, 17–28 were isolated from the Viburnum genus for the first time. The anti-inflammatory and antioxidant activities of all compounds were evaluated in vitro. Compounds 15, 19, 20 and 29 showed significant inhibitory activity on NO production in RAW264.7 cells stimulated by LPS with IC50 values ranging from 8.60 to 13.92 μM. Meanwhile, compounds 14, 15, 19, 20, 22, 23, 25, 26 and 29 exhibited varying antioxidant activities through DPPH, ABTS free radical scavenging and FRAP assays.

Keywords

Viburnum fordiae Hance Neolignan Anti-inflammatory Antioxidant 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 31201563); Open foundation of green pesticides and biotechnology key laboratory of Guizhou University of Ministry of Education (2017GDGP0102/2017GDGP0103). We are also grateful to the Analytical Detective Center, Yangzhou University, for recording CD, IR, UV, MS and NMR spectra.

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest.

Supplementary material

12272_2018_1026_MOESM1_ESM.docx (3.1 mb)
Supplementary material 1 (DOCX 3159 kb)

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Copyright information

© The Pharmaceutical Society of Korea 2018

Authors and Affiliations

  1. 1.Jiangsu Key Laboratory of Crop Genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain CropsYangzhou UniversityYangzhouPeople’s Republic of China
  2. 2.College of Bioscience and BiotechnologyYangzhou UniversityYangzhouPeople’s Republic of China
  3. 3.School of PharmacyShenyang Pharmaceutical UniversityShenyangPeople’s Republic of China
  4. 4.School of PharmacyGuizhou Medical UniversityGuiyangPeople’s Republic of China

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