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Archives of Pharmacal Research

, Volume 41, Issue 4, pp 431–437 | Cite as

New limonophyllines A-C from the stem of Atalantia monophylla and cytotoxicity against cholangiocarcinoma and HepG2 cell lines

  • Aonnicha Sombatsri
  • Yutthapong Thummanant
  • Thurdpong Sribuhom
  • Jaursup Boonmak
  • Sujittra Youngme
  • Suphanthip Phusrisom
  • Veerapol Kukongviriyapan
  • Chavi YenjaiEmail author
Research Article
  • 302 Downloads

Abstract

Three new limonoids, limonophyllines A-C (1, 4 and 5), along with two known limonoids (2 and 3) and 11 acridone alkaloids (6-16) were isolated from the stems of Atalantia monophylla. All isolates were evaluated against cholangiocarcinoma, KKU-M156, and HepG2 cancer cell lines. Compounds 12, 14 and 16 displayed cytotoxicity against KKU-M156 cell line with IC50 ranging from 3.39 to 4.1 μg/mL while cytotoxicity against HepG2 cell line with IC50 ranging from 1.43 to 8.4 μg/mL. The structures of all isolated compounds were established by spectroscopic methods including 1D and 2D NMR, IR and mass spectrometry.

Keywords

Atalantia monophylla Limonophylline Acridones Cholangiocarcinoma HepG2 

Notes

Acknowledgements

We thank the Science Achievement Scholarship of Thailand (SAST) for the support to A. Sombatsri. We acknowledge the Thai Research Fund (RSA5980022) and Khon Kaen University for financial support. The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education is gratefully acknowledged.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to report.

Supplementary material

12272_2018_1021_MOESM1_ESM.docx (2.3 mb)
Supplementary material 1 (DOCX 2384 kb)

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Copyright information

© The Pharmaceutical Society of Korea 2018

Authors and Affiliations

  • Aonnicha Sombatsri
    • 1
  • Yutthapong Thummanant
    • 1
  • Thurdpong Sribuhom
    • 1
  • Jaursup Boonmak
    • 2
  • Sujittra Youngme
    • 2
  • Suphanthip Phusrisom
    • 3
  • Veerapol Kukongviriyapan
    • 3
  • Chavi Yenjai
    • 1
    Email author
  1. 1.Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of ScienceKhon Kaen UniversityKhon KaenThailand
  2. 2.Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of ScienceKhon Kaen UniversityKhon KaenThailand
  3. 3.Department of Pharmacology, Faculty of MedicineKhon Kaen UniversityKhon KaenThailand

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