Saroclazines A–C, thio-diketopiperazines from mangrove-derived fungi Sarocladium kiliense HDN11-84
- 283 Downloads
Three new diketopiperazine derivatives (DKPs), saroclazines A–C (1–3) along with three known DKPs (4–6) were isolated from mangrove-derived fungi Sarocladium kiliense HDN11-84. Saroclazines A–B (1 and 2) possessed a free amide structure, which was first found in sulfur-containing aromatic DKPs. Their structures were elucidated by NMR, HRESIMS and X-ray. The cytotoxic activity of new compounds (1–3) was tested against HeLa cell lines, among which compound 2 showed an IC50 value of 4.2 µM.
KeywordsFungi Mangrove Sarocladium kiliense Cytotoxic activity
This work was financially supported by the Chinese National Natural Science Fund (21372208 and 21542001), Shandong Provincial Natural Science Fund for Distinguished Young Scholars (JQ201422), NSFC–Shandong Joint Fund for Marine Science Research Centers (U1606402), AoShan Talents Program Supported by Qingdao National Laboratory for Marine Science and Technology (2015ASTP-ES09) and Fundamental Research Funds for the Central Universities (201564026).
- Fernandez-Silva F, Capilla J, Mayayo E, Sutton D, Guarro J (2014b) In vitro evaluation of antifungal drug combinations against Sarocladium (Acremonium) kiliense, an opportunistic emergent fungus resistant to antifungal therapies. Antimicrob Agents Chemother 58:1259–1260CrossRefPubMedPubMedCentralGoogle Scholar
- Rambaud M, Grizzi L (1973) Proteolytic enzyme by fermentation. Ger Offen DE 2238282 A1 19730315Google Scholar