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Archives of Pharmacal Research

, Volume 41, Issue 12, pp 1170–1177 | Cite as

Limonoids from the roots of Trichilia sinensis and their cytotoxicities

  • Shou-Bai Liu
  • Wen-Li Mei
  • Hui-Qin Chen
  • Jun Wang
  • Zhu-Nian WangEmail author
  • Hao-Fu DaiEmail author
Research Article
  • 527 Downloads

Abstract

Six new compounds (14, 8, 10), along with six known limonoids (5–7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including 1H NMR, 13C NMR, DEPT, HSQC, HMBC, 1H–1H COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines.

Keywords

Trichilia sinensis Roots Trichilin-type limonoids Cytotoxic activities 

Notes

Acknowledgements

This research was financially supported by the Special Fund for Agro-scientific Research in the Public Interest (201303117), Special Grant for Modernization of Traditional Chinese Medicine of Hainan Province (2015ZY04) and Key Research and Development Scheme of Hainan Province (ZDYF2016140).

Compliance with ethical standards

Conflict of interest

All the authors have no conflict of interest to declare.

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Copyright information

© The Pharmaceutical Society of Korea 2017

Authors and Affiliations

  1. 1.Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikouPeople’s Republic of China
  2. 2.Tropical Crops Genetic Resources InstituteChinese Academy of Tropical Agricultural SciencesDanzhouPeople’s Republic of China

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