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Archives of Pharmacal Research

, Volume 40, Issue 6, pp 655–675 | Cite as

Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities

  • Yun-Seo Kil
  • Sally T. Pham
  • Eun Kyoung SeoEmail author
  • Mahtab JafariEmail author
Review

Abstract

Angelica keiskei (Miq.) Koidz. (Umbelliferae) has traditionally been used to treat dysuria, dyschezia, and dysgalactia as well as to restore vitality. Recently, the aerial parts of A. keiskei have been consumed as a health food. Various flavonoids, coumarins, phenolics, acetylenes, sesquiterpene, diterpene, and triterpenes were identified as the constituents of A. keiskei. The crude extracts and pure constituents were proven to inhibit tumor growth and ameliorate inflammation, obesity, diabetics, hypertension, and ulcer. The extract also showed anti-thrombotic, anti-oxidative, anti-hyperlipidemic, anti-viral, and anti-bacterial activities. This valuable herb needs to be further studied and developed not only to treat these human diseases but also to improve human health. Currently A. keiskei is commercialized as a health food and additives in health drinks. This article presents a comprehensive review of A. keiskei and its potential place in the improvement of human health.

Keywords

Angelica keiskei Umbelliferae Chemical constituent Biological activity 

Notes

Acknowledgements

This work is supported by Ewha Womans University (collaborative research grant for Ewha-UC Irvine).

Compliance with ethical standards

Conflict of interest

The co-authors have declared no conflict of interest.

References

  1. Akihisa T, Tokuda H, Ukiya M, Iizuka M, Schneider S, Ogasawara K, Mukainaka T, Iwatsuki K, Suzuki T, Nishino H (2003) Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects. Cancer Lett 201:133–137CrossRefPubMedGoogle Scholar
  2. Akihisa T, Tokuda H, Hasegawa D, Ukiya M, Kimura Y, Enjo F, Suzuki T, Nishino H (2006) Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects. J Nat Prod 69:38–42CrossRefPubMedGoogle Scholar
  3. Akihisa T, Yasukawa T, Ukiya M, Hasegawa D (2007) Anti-inflammatory agents containing natural products from Angelica keiskei. (Nihon University, Japan). Application: JPGoogle Scholar
  4. Akihisa T, Kikuchi T, Nagai H, Ishii K, Tabata K, Suzuki T (2011) 4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells. J Oleo Sci 60:71–77CrossRefPubMedGoogle Scholar
  5. Aoki N, Ohta S (2010) Ashitabaol A, a new antioxidative sesquiterpenoid from seeds of Angelica keiskei. Tetrahedron Lett 51:3449–3450CrossRefGoogle Scholar
  6. Aoki N, Muko M, Ohta E, Ohta S (2008) C-Geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity. J Nat Prod 71:1308–1310CrossRefPubMedGoogle Scholar
  7. Arung ET, Furuta S, Sugamoto K, Shimizu K, Ishikawa H, Matsushita Y-I, Kondo R (2012) The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells. Nat Prod Commun 7:1007–1010PubMedGoogle Scholar
  8. Baba K, Kido T, Yoneda Y, Taniguchi M, Kozawa M (1990a) Chemical components of Angelica keiskei Koidzumi. (V). Components of the fruits, and comparison of coumarins and chalcones in the fruits, roots and the leaves. Shoyakugaku Zasshi 44:235–239Google Scholar
  9. Baba K, Nakata K, Taniguchi M, Kido T, Kozawa M (1990b) Chemical components of Angelica keiskei. Part 7. Chalcones from Angelica keiskei. Phytochemistry 29:3907–3910CrossRefGoogle Scholar
  10. Baba K, Taniguchi M, Nakata K (1998) Studies on Angelica keiskei “Ashitaba”. Foods Food Ingred J Jpn 178:52–60Google Scholar
  11. Bao G (2014) Angelica keiskei-containing nutritional and health-protecting flour and its preparation method (Qingyang county nanyang rice industry Co., Ltd, Peop. Rep. China). Application: CNGoogle Scholar
  12. Battenberg OA, Yang Y, Verhelst SHL, Sieber SA (2013) Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification. Mol BioSyst 9:343–351CrossRefPubMedGoogle Scholar
  13. Chang HR, Lee HJ, Ryu J-H (2014) Chalcones from Angelica keiskei attenuate the inflammatory responses by suppressing nuclear translocation of NF-κB. J Med Food 17:1306–1313CrossRefPubMedGoogle Scholar
  14. Enoki T, Ohnogi H, Nagamine K, Kudo Y, Sugiyama K, Tanabe M, Kobayashi E, Sagawa H, Kato I (2007) Antidiabetic activities of chalcones isolated from a Japanese herb, Angelica keiskei. J Agric Food Chem 55:6013–6017CrossRefPubMedGoogle Scholar
  15. Fujita T, Sakuma S, Sumiya T, Nishida H, Fujimoto Y, Baba K, Kozawa M (1992) The effects of xanthoangelol E on arachidonic acid metabolism in the gastric antral mucosa and platelet of the rabbit. Res Commun Chem Pathol Pharmacol 77:227–240PubMedGoogle Scholar
  16. Fukuo Y, Ogasawara K, Satoh K (2005) Antimicrobial agent/Antimicrobial agent against Helicobacter pylori comprising a material derived from Angelica keiskei (Japan Bio Science Laboratory Co., Ltd., Japan). Application: USGoogle Scholar
  17. Guo X-Q, Wu J-H, Liu C, Li J-Q, Wang Z-W, Yang K-F (2013) Comparison of antioxidant content and oxidation resistance of stems and leaves from Angelica keiskei Koidzmi. Shipin Yu Fajiao Gongye 39:122–127Google Scholar
  18. Hata K, Kozawa M (1961) Pharmacognostical studies on umbelliferous plants. XVIII. Constituents of the roots of Angelica keiskei. Yakugaku Zasshi 81:1647–1649CrossRefPubMedGoogle Scholar
  19. Higa Y (1985) Skin-whitening cosmetic containing Angelica keiskei Koidzumi extract and having tyrosinase inhibiting effect (Sansei Pharmaceutical Co., Ltd., Japan). Application: JPGoogle Scholar
  20. Imai K, Imai M (2008) Encyclopedia of wild herbs and vegetables. Green Home, SeoulGoogle Scholar
  21. Inamori Y, Baba K, Tsujibo H, Taniguchi M, Nakata K, Kozawa M (1991) Chemical components of Angelica keiskei. VI. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei Koidzumi. Chem Pharm Bull 39:1604–1605CrossRefPubMedGoogle Scholar
  22. Jeong Y-J, Kang KJ (2011) Effect of Angelica keiskei extract on apoptosis of MDA-MB-231 human breast cancer cells. Han’guk Sikp’um Yongyang Kwahak Hoechi 40:1654–1661Google Scholar
  23. Kang M-H, Park YK, Kim H-Y, Kim TS (2004) Green vegetable drink consumption protects peripheral lymphocytes DNA damage in Korean smokers. BioFactors 22:245–247CrossRefPubMedGoogle Scholar
  24. Kawabata K-I, Sawada K, Ikeda K, Fukuda I, Kawasaki K, Yamamoto N, Ashida H (2011) Prenylated chalcones 4-hydroxyderricin and xanthoangelol stimulate glucose uptake in skeletal muscle cells by inducing GLUT4 translocation. Mol Nutr Food Res 55:467–475CrossRefPubMedGoogle Scholar
  25. Kil Y-S, Choi S-K, Lee Y-S, Jafari M, Seo E-K (2015a) Chalcones from Angelica keiskei: evaluation of their heat shock protein inducing activities. J Nat Prod 78:2481–2487CrossRefPubMedGoogle Scholar
  26. Kil Y-S, Nam J-W, Lee J, Seo EK (2015b) Separation of two major chalcones from Angelica keiskei by high-speed counter-current chromatography. Arch Pharmacal Res 38:1506–1511CrossRefGoogle Scholar
  27. Kil Y-S, Kwon J, Lee D, Seo EK (2016) Three new chalcones from the aerial parts of Angelica keiskei. Helv Chim Acta 99:393–397CrossRefGoogle Scholar
  28. Kim S-J, Cho J-Y, Wee J-H, Jang M-Y, Kim C, Rim Y-S, Shin S-C, Ma S-J, Moon J-H, Park K-H (2005) Isolation and characterization of antioxidative compounds from the aerial parts of Angelica keiskei. Food Sci Biotechnol 14:58–63Google Scholar
  29. Kim TS, Shim JS, Kim SD, Yeo IH (2006) Health-aid food, drink and food composition having hepato-protective effect, which comprises Angelica keiskei root extract and hydroxyderricin and xanthoangelol isolated therefrom (Pulmuone Co., Ltd., S. Korea). Application: KRGoogle Scholar
  30. Kim E, Choi J, Yeo I (2012) The effects of Angelica keiskei Koidz on the expression of antioxidant enzymes related to lipid profiles in rats fed a high fat diet. Nutr Res Pract 6:9–15CrossRefPubMedPubMedCentralGoogle Scholar
  31. Kim JH, Son YK, Kim GH, Hwang KH (2013) Xanthoangelol and 4-hydroxyderricin are the major active principles of the inhibitory activities against monoamine oxidases on Angelica keiskei K. Biomol Ther 21:234–240CrossRefGoogle Scholar
  32. Kim DW, Curtis-Long MJ, Yuk HJ, Wang Y, Song YH, Jeong SH, Park KH (2014) Quantitative analysis of phenolic metabolites from different parts of Angelica keiskei by HPLC-ESI MS/MS and their xanthine oxidase inhibition. Food Chem 153:20–27CrossRefPubMedGoogle Scholar
  33. Kimura Y, Baba K (2003) Antitumor and antimetastatic activities of Angelica keiskei roots, part 1: isolation of an active substance, xanthoangelol. Int J Cancer 106:429–437CrossRefPubMedGoogle Scholar
  34. Kimura Y, Taniguchi M, Baba K (2004) Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots. Planta Med 70:211–219CrossRefPubMedGoogle Scholar
  35. Kimura Y, Sumiyoshi M, Baba K (2008) Anti-tumor actions of major component 3′-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation. Cancer Lett 265:84–97CrossRefPubMedGoogle Scholar
  36. Kishiro S, Nunomura S, Nagai H, Akihisa T, Ra C (2008) Selinidin suppresses IgE-mediated mast cell activation by inhibiting multiple steps of FcεRI signaling. Biol Pharm Bull 31:442–448CrossRefPubMedGoogle Scholar
  37. Kozawa M, Morita N, Baba K, Hata K (1977) The structure of xanthoangelol, a new chalcone from the roots of Angelica keiskei Koidzumi (Umbelliferae). Chem Pharm Bull 25:515–516CrossRefGoogle Scholar
  38. Kozawa M, Morita N, Baba K, Hata K (1978) Chemical components of the roots of Angelica keiskei Koidzumi. III. The structure of a new dihydrofurocoumarin. Yakugaku Zasshi 98:636–638CrossRefPubMedGoogle Scholar
  39. Ku CS, Kim MJ, Jung YJ, Jang DI (2014) Cosmetic compositions containing Angelica keiskei extracts (COTDE Co., Ltd., S. Korea). Application: KRGoogle Scholar
  40. Kusaba N, Kamiya T, Ikeguchi M, Ono H, Takagaki K, Hayashi M, Ogasawara T, Sugawa-Katayama Y (2008) Effects of AOJIRU drink powder of Angelica keiskei leaf containing indigestible dextrin on defecation in volunteers with constipation. Jpn Pharmacol Ther 36:1159–1165Google Scholar
  41. Lee HJ, Choi TW, Kim HJ, Nam D, Jung SH, Lee EH, Lee HJ, Shin EM, Jang H-J, Ahn KS, Shim BS, Choi S-H, Kim S-H, Sethi G, Ahn KS (2010) Anti-inflammatory activity of Angelica keiskei through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways. J Med Food 13:691–699CrossRefPubMedGoogle Scholar
  42. Lee MS, Jung MG, Choi GB, Kim TS, Yeo IH, Nam SU (2012a) Angelica keiskei extracts for preventing and treating obesity (Pulmuone Holdings Co., Ltd., S. Korea). Application: KRGoogle Scholar
  43. Lee MS, Kim BG, Choi GB, Kim TS, Yeo IH, Nam SU (2012b) Skin whitening composition containing Angelica keiskei extracts (Pulmuone Holdings Co., Ltd., S. Korea). Application: KRGoogle Scholar
  44. Lee MS, Lee EJ, Choi GB, Kim TS, Yeo IH, Nam SU (2013) Angelica keiskei extracts for preventing and alleviating diabetes mellitus (Pulmuone Holdings Co., Ltd., S. Korea). Application: KRGoogle Scholar
  45. Lee MS, Choi GB, Kim TS, Yeo IH, Nam SU (2014) Angelica keiskei root extracts for inducing apoptosis of prostate cancer cells (Pulmuone Co., Ltd., S. Korea). Application: KRGoogle Scholar
  46. Li J-L, Gao L-X, Meng F-W, Tang C-L, Zhang R-J, Li J-Y, Luo C, Li J, Zhao W-M (2015) PTP1B inhibitors from stems of Angelica keiskei (Ashitaba). Bioorg Med Chem Lett 25:2028–2032CrossRefPubMedGoogle Scholar
  47. Liu X, Wang Z, Sun J, Wan Y, Rong Y (2014) Coix seed-Angelica keiskei nutritional health-care biscuits and production method thereof (Shanghai Jiao Tong University, Peop. Rep. China). Application: CNGoogle Scholar
  48. Luo L, Wang R, Wang X, Ma Z, Li N (2012) Compounds from Angelica keiskei with NQO1 induction, DPPH· scavenging and α-glucosidase inhibitory activities. Food Chem 131:992–998CrossRefGoogle Scholar
  49. Matsuura M, Kimura Y, Nakata K, Baba K, Okuda H (2001) Artery relaxation by chalcones isolated from the roots of Angelica keiskei. Planta Med 67:230–235CrossRefPubMedGoogle Scholar
  50. Motani K, Tabata K, Kimura Y, Okano S, Shibata Y, Abiko Y, Nagai H, Akihisa T, Suzuki T (2008) Proteomic analysis of apoptosis induced by xanthoangelol, a major constituent of Angelica keiskei, in neuroblastoma. Biol Pharm Bull 31:618–626CrossRefPubMedGoogle Scholar
  51. Murakami S, Kijima H, Isobe Y, Muramatsu M, Aihara H, Otomo S, Baba K, Kozawa M (1990) Inhibition of gastric H+, K+-ATPase by chalcone derivatives, xanthoangelol and 4-hydroxyderricin, from Angelica keiskei Koidzumi. J Pharm Pharmacol 42:723–726CrossRefPubMedGoogle Scholar
  52. Murakami S, Kotomo S, Ozawa M, Baba K (1992) Novel chalcone derivative as antiulcer agent (Taisho Pharmaceutical Co., Ltd., Japan). Application: JPGoogle Scholar
  53. Nakata K, Baba K (2001) Histamine release-inhibiting activity of Angelica keiskei. Nat Med 55:32–34Google Scholar
  54. Nakata K, Katsumata H, Taniguchi M, Kita S, Baba K (1997) Comparison of the characteristics and the constituents of Angelica keiskei KOIDZUMI growing in Hachijo and Oshima. Nat Med 51:532–536Google Scholar
  55. Nakata K, Taniguchi M, Baba K (1999) Three chalcones from Angelica keiskei. Nat Med 53:329–332Google Scholar
  56. Nishimura R, Tabata K, Arakawa M, Ito Y, Kimura Y, Akihisa T, Nagai H, Sakuma A, Kohno H, Suzuki T (2007) Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma. Biol Pharm Bull 30:1878–1883CrossRefPubMedGoogle Scholar
  57. Noh H-M, Ahn E-M, Yun J-M, Cho B-L, Paek Y-J (2015) Angelica keiskei Koidzumi extracts improve some markers of liver function in habitual alcohol drinkers: a randomized double-blind clinical trial. J Med Food 18:166–172CrossRefPubMedGoogle Scholar
  58. Ogawa H, Nakashima S, Baba K (2003) Effects of dietary Angelica keiskei on lipid metabolism in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 30:284–288CrossRefPubMedGoogle Scholar
  59. Ogawa H, Nakamura R, Baba K (2005a) Beneficial effect of laserpitin, a coumarin compound from Angelica keiskei, on lipid metabolism in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 32:1104–1109CrossRefPubMedGoogle Scholar
  60. Ogawa H, Ohno M, Baba K (2005b) Hypotensive and lipid regulatory actions of 4-hydroxyderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 31:19–23CrossRefGoogle Scholar
  61. Oh SR, Kim S-J, Kim DH, Ryu JH, Ahn E-M, Jung JW (2013) Angelica keiskei ameliorates scopolamine-induced memory impairments in mice. Biol Pharm Bull 36:82–88CrossRefPubMedGoogle Scholar
  62. Ohkura N, Nakakuki Y, Taniguchi M, Kanai S, Nakayama A, Ohnishi K, Sakata T, Nohira T, Matsuda J, Baba K, Atsumi G-I (2011) Xanthoangelols isolated from Angelica keiskei inhibit inflammatory-induced plasminogen activator inhibitor 1 (PAI-1) production. BioFactors 37:455–461CrossRefPubMedGoogle Scholar
  63. Ohnogi H, Shiraga M, Sagawa H, Kato I (2002) Nerve growth factor enhancers for treatment of disease containing coumarin and/or chroman derivatives (Takara Bio Inc., Japan). Application: WOGoogle Scholar
  64. Ohnogi H, Sugiyama K, Muraki N, Sagawa H, Kato I (2004) Plant components for promoting osteogenesis (Takara Bio Inc., Japan). Application: WOGoogle Scholar
  65. Ohnogi H, Enoki T, Hino F, Kato I (2007) Antidiabetic effect and safety of long-term ingestion of Ashitaba (Angelica keiskei) powder containing Chalcone (4HD) on borderline mild hyperglycemia. Jpn Pharmacol Ther 35:647–660Google Scholar
  66. Ohnogi H, Hayami S, Kudo Y, Deguchi S, Mizutani S, Enoki T, Tanimura Y, Aoi W, Naito Y, Kato I, Yoshikawa T (2012a) Angelica keiskei extract improves insulin resistance and hypertriglyceridemia in rats fed a high-fructose drink. Biosci Biotechnol Biochem 76:928–932CrossRefPubMedGoogle Scholar
  67. Ohnogi H, Kudo Y, Tahara K, Sugiyama K, Enoki T, Hayami S, Sagawa H, Tanimura Y, Aoi W, Naito Y, Kato I, Yoshikawa T (2012b) Six new chalcones from Angelica keiskei inducing adiponectin production in 3T3-L1 adipocytes. Biosci Biotechnol Biochem 76:961–966CrossRefPubMedGoogle Scholar
  68. Oi J, Meyer FG, Meyer FG, Walker EH (1965) Flora of Japan: in English: combined, much revised and extended translation/by the author of his Flora of Japan (1953) and Flora of Japan, Pteridophyta (1957); edited by Frederick G. Meyer and Egbert H. Walker. Washington, Smithsonian InstitutionCrossRefGoogle Scholar
  69. Okuyama T, Takata M, Takayasu J, Hasegawa T, Tokuda H, Nishino A, Nishino H, Iwashima A (1991) Anti-tumor-promotion by principles obtained from Angelica keiskei. Planta Med 57:242–246CrossRefPubMedGoogle Scholar
  70. Onogi H, Sugiyama K, Muraki N, Enoki T, Sagawa H, Kato I (2004) Chalcone derivatives from Angelica and pharmacological activities thereof (Takara Bio Inc., Japan). Application: WOGoogle Scholar
  71. Park J-C (2013) The medicinal herbs, teas, and alcoholic beverages in Donguibogam, proven by patents. Pureun-Hyeongbok Publisher, GoyangGoogle Scholar
  72. Park JC, Cho YS, Park SK, Park JR, Chun SS, Ok KD, Choi JW (1995) Isolation of flavone-7-O-glycosides from the aerial parts of Angelica keiskei and antihyperlipidemic effects. Saengyak Hakhoechi 26:337–343Google Scholar
  73. Park JC, Yu YB, Lee JH, Choi MR, Ok KD (1996) Chemical components from the aerial parts of Angelica keiskei. Saengyak Hakhoechi 27:80–82Google Scholar
  74. Park J-C, Park J-R, Chung S-K, Yu Y-B, Ha J-O, Park K-Y (1997a) Antimutagenic activity of the methanol extract and compounds of Angelica keiskei in the Salmonella assay system. Saengyak Hakhoechi 28:80–83Google Scholar
  75. Park J-R, Park J-C, Choi S-H (1997b) Screening and characterization of anticholesterogenic substances from food plant extracts. Han’guk Sikp’um Yongyang Kwahak Hoechi 26:236–241Google Scholar
  76. Park JC, Park JG, Kim HJ, Hur JM, Lee JH, Sung NJ, Chung SK, Choi JW (2002) Effects of extract from Angelica keiskei and its component, cynaroside, on the hepatic bromobenzene-metabolizing enzyme system in rats. Phytother Res 16:S24–S27CrossRefPubMedGoogle Scholar
  77. Park J-Y, Jeong HJ, Kim YM, Park S-J, Rho M-C, Park KH, Ryu YB, Lee WS (2011) Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition. Bioorg Med Chem Lett 21:5602–5604CrossRefPubMedGoogle Scholar
  78. Park JY, Ko Jin A, Kim Dae W, Kim Young M, Kwon HJ, Jeong Hyung J, Kim Cha Y, Park Ki H, Lee Woo S, Ryu Young B (2015) Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV. J Enzym Inhib Med Chem: 1–8Google Scholar
  79. Qin LQ, Luo SY, Zhan ZH, Liu XX, Wang K (2014) Determination of antioxidant compounds from leaf and stem of Angelica keiskei by gas chromatography-mass spectrometry. Asian J Chem 26:5097–5099Google Scholar
  80. Saeki Y, Asada S, Kikuchi S, Itoh S (2013) Deodorant composition containing extracts of Angelica keiskei for prevention of mouth odor (Lotte Co., Ltd., Japan). Application: WO; Chemical Indexing Equivalent to 158:544360 (JP)Google Scholar
  81. Sakaguchi Y, Sakaguchi M, Sakaguchi T (1996) Hair growth promoter comprising Angelica keiskei extract, and preparation method thereof (Japan). Application: JPGoogle Scholar
  82. Shimizu E, Hayashi A, Takahashi R, Aoyagi Y, Murakami T, Kimoto K (1999) Effects of angiotensin 1-converting enzyme inhibitor from Ashitaba (Angelica keiskei) on blood pressure of spontaneously hypertensive rats. J Nutr Sci Vitaminol 45:375–383CrossRefPubMedGoogle Scholar
  83. Shin JE, Choi EJ, Jin Q, Jin H-G, Woo E-R (2011) Chalcones isolated from Angelica keiskei and their inhibition of IL-6 production in TNF-α-stimulated MG-63 cell. Arch Pharmacal Res 34:437–442CrossRefGoogle Scholar
  84. Shin H-J, Shon D-H, Youn H-S (2013) Isobavachalcone suppresses expression of inducible nitric oxide synthase induced by Toll-like receptor agonists. Int Immunopharmacol 15:38–41CrossRefPubMedGoogle Scholar
  85. Son DJ, Park YO, Yu C, Lee SE, Park YH (2014) Bioassay-guided isolation and identification of anti-platelet-active compounds from the root of Ashitaba (Angelica keiskei Koidz.). Nat Prod Res 28:2312–2316CrossRefPubMedGoogle Scholar
  86. Su L (2014) A method for preparing Angelica keiskei wine (Nanjing Zelang Agriculture Development Co., Ltd., Peop. Rep. China). Application: CNGoogle Scholar
  87. Sugamoto K, Matsushita Y-I, Matsui T, Kurogi C, Park JC (2008) Isolation and analysis components of Ashitaba (Angelica keiskei koidzumi) leaves growing in Miyazaki and Korea. Mem Fac Eng Miyazaki Univ 37:75–80Google Scholar
  88. Sugamoto K, Matsushita Y-I, Matsui T, Hikita H, Park JC (2009) Isolation and analysis components of Ashitaba (Angelica keiskei Koidzumi) roots, stems and leaves. Mem Fac Eng Miyazaki Univ 38:91–96Google Scholar
  89. Sugamoto K, Matsusita Y-I, Matsui K, Kurogi C, Matsui T (2011) Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei. Tetrahedron 67:5346–5359CrossRefGoogle Scholar
  90. Sugii M, Ohkita M, Taniguchi M, Baba K, Kawai Y, Tahara C, Takaoka M, Matsumura Y (2005) Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-κB. Biol Pharm Bull 28:607–610CrossRefPubMedGoogle Scholar
  91. Tabata K, Motani K, Takayanagi N, Nishimura R, Asami S, Kimura Y, Ukiya M, Hasegawa D, Akihisa T, Suzuki T (2005) Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells. Biol Pharm Bull 28:1404–1407CrossRefPubMedGoogle Scholar
  92. Takaoka S, Hibasami H, Ogasawara K, Imai N (2008) Chalcones from Angelica keiskei induced apoptosis in stomach cancer cells. J Herbs, Spices Med Plants 14:166–174CrossRefGoogle Scholar
  93. Yasuda M, Kawabata K, Miyashita M, Okumura M, Yamamoto N, Takahashi M, Ashida H, Ohigashi H (2014) Inhibitory effects of 4-hydroxyderricin and xanthoangelol on lipopolysaccharide-induced inflammatory responses in RAW264 macrophages. J Agric Food Chem 62:462–467CrossRefPubMedGoogle Scholar
  94. Zhang T, Sawada K, Yamamoto N, Ashida H (2013) 4-Hydroxyderricin and xanthoangelol from Ashitaba (Angelica keiskei) suppress differentiation of preadiopocytes to adipocytes via AMPK and MAPK pathways. Mol Nutr Food Res 57:1729–1740PubMedGoogle Scholar
  95. Zhang T, Yamashita Y, Yasuda M, Yamamoto N, Ashida H (2015) Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice. Food Funct 6:134–145CrossRefGoogle Scholar
  96. Zhou X, Liang C, Xu Q, Zhang X, Liang X, Huang Q, Su X (2012) Chemical constituents of Angelica keiskei. Zhongguo Shiyan Fangjixue Zazhi 18:103–105Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 2017

Authors and Affiliations

  1. 1.College of Pharmacy, Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulKorea
  2. 2.Department of Pharmaceutical SciencesUniversity of CaliforniaIrvineUSA

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