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Pestalotic acids A-I, antibacterial ambuic acid analogues, from a mycoparasite (Pestalotipsis sp. cr014) of Cronartium ribicola

  • Jing Li
  • Jin Xie
  • Fei-Xue Yu
  • Yu-Hui Chen
  • Pei-Ji ZhaoEmail author
Research Article

Abstract

The white pine blister rust caused by Cronartium ribicola is a severe disease of Pinus armandii Franch in Sichuan Province, China. A mycoparasite was isolated from aeciospore piles of C. ribicola and identified as Pestalotipsis sp. The chemical constituents were investigated and nine new polyketides, named pestalotic acids A-I (19), were isolated from solid fermentation products of Pestalotiopsis sp. cr014. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D- NMR, HR-MS experiments. Compounds 2–5 and 79 exhibited strong antibacterial activities in vitro against five plant pathogens, with minimum inhibitory concentration values of 0.78–100 µg/mL.

Keywords

Pestalotiopsis sp. cr014 Pestalotic acid Polyketide Antibacterial activity Plant pathogen 

Notes

Acknowledgments

This work was supported by the National Basic Research Program of China (973 program 2013CB127505), the National Natural Science Foundation of China (31170061 and 31360028), and the Applied Basic Research Foundation of Yunnan Province (2013FA018). We acknowledge the Department of Instrumental Analysis of Kunming Institute of Botany for measuring the optical rotations, UV, NMR and mass spectra.

Compliance with ethical standards

Conflict of interest

Authors declare no competing financial interests associated with the manuscript exist.

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Copyright information

© The Pharmaceutical Society of Korea 2016

Authors and Affiliations

  1. 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of BotanyChinese Academy of SciencesKunmingChina
  2. 2.State Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanYunnan UniversityKunmingChina
  3. 3.Life Science CollegeSouthwest Forestry UniversityKunmingChina
  4. 4.University of Chinese Academy of SciencesBeijingChina

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