Pestalotic acids A-I, antibacterial ambuic acid analogues, from a mycoparasite (Pestalotipsis sp. cr014) of Cronartium ribicola
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The white pine blister rust caused by Cronartium ribicola is a severe disease of Pinus armandii Franch in Sichuan Province, China. A mycoparasite was isolated from aeciospore piles of C. ribicola and identified as Pestalotipsis sp. The chemical constituents were investigated and nine new polyketides, named pestalotic acids A-I (1–9), were isolated from solid fermentation products of Pestalotiopsis sp. cr014. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D- NMR, HR-MS experiments. Compounds 2–5 and 7–9 exhibited strong antibacterial activities in vitro against five plant pathogens, with minimum inhibitory concentration values of 0.78–100 µg/mL.
KeywordsPestalotiopsis sp. cr014 Pestalotic acid Polyketide Antibacterial activity Plant pathogen
This work was supported by the National Basic Research Program of China (973 program 2013CB127505), the National Natural Science Foundation of China (31170061 and 31360028), and the Applied Basic Research Foundation of Yunnan Province (2013FA018). We acknowledge the Department of Instrumental Analysis of Kunming Institute of Botany for measuring the optical rotations, UV, NMR and mass spectra.
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Conflict of interest
Authors declare no competing financial interests associated with the manuscript exist.
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