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Archives of Pharmacal Research

, Volume 39, Issue 10, pp 1382–1390 | Cite as

Novel hybrids of drug with bioactive heterocycles for enhancing biological activity

  • Parthiban ValentinaEmail author
  • Kaliappan Ilango
  • Muthu K. Kathiravan
Research Article

Abstract

A novel series of aceclofenac hybridised with 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles were designed using molecular hybridization approach and synthesised 6aj. The structural integrity was confirmed by analytical methods. The hybrid molecules were subjected to in vitro cytotoxic studies against four human cancer cell lines PA‐1, OAW‐42, T47-D and MCF‐7 by MTT assay method. The results indicate that the hybrid molecules bearing halogen on phenyl ring in 6th position of triazolo-thiadiazole exhibited significant cytotoxic activity. The test compounds were also screened for antifungal activity against two strains.

Keywords

Triazolo-thiadiazole Cytotoxic Molecular hybrids 

Notes

Acknowledgments

The authors greatly acknowledge their thanks to Dr K. S. Lakshmi, Dean, College of Pharmacy, S.R.M University, Chennai for providing the facilities to carry out this work.

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Copyright information

© The Pharmaceutical Society of Korea 2016

Authors and Affiliations

  • Parthiban Valentina
    • 1
    Email author
  • Kaliappan Ilango
    • 2
  • Muthu K. Kathiravan
    • 2
  1. 1.Department of Pharmaceutical ChemistryJaya College of Paramedical Sciences, College of PharmacyChennaiIndia
  2. 2.Department of Pharmaceutical Chemistry, SRM College of PharmacySRM UniversityKancheepuramIndia

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