Archives of Pharmacal Research

, Volume 39, Issue 2, pp 202–212 | Cite as

Formulation of nimodipine nanocrystals for oral administration

  • Jianwen Li
  • Qiang FuEmail author
  • Xiaohong Liu
  • Mo Li
  • Yongjun WangEmail author
Research Article


The aim of this paper is to optimize nimodipine (NMD) nanocrystals (NCs) for oral administration. The effects of independent process variables (microprecipitation temperature, shearing speed, shearing time, homogenization pressure and number of cycles) on the particle size have been studied. Experiments were conducted to optimize the formulation composition. A single factor exploration was used to screen the primary stabilizers. Then, the selected polymers/surfactants were further optimized using an L9 (34) orthogonal design. The optimal formulation was composed of NMD (0.7 %, w/v), F127 (0.4 %, w/v), HPMC-E5 (0.1 %, w/v), and sodium deoxycholate (0.05 %, w/v) and was rod-shaped as shown by SEM observations, and it had a particle size of 833.3 ± 20.6 nm, determined by laser diffraction. These aqueous NCs were physically stable for 15 days. To further improve the stability, the NCs were freeze-dried. The powder obtained exhibited acceptable flowability and was physically stable for at least 24 months. Additionally, the NMD NCs displayed much higher dissolution profiles than the bulk drug. The pharmacokinetic results showed that the relative bioavailability was 397 % in comparison with Nimotop®, suggesting that NCs are an efficient strategy for improving the oral bioavailability of poorly water-soluble drugs.


Nimodipine Nanocrystals Preparation Formulation Physical stability 



This work was financially supported by Doctoral Research Funding of Liaoning Province (No. 20141066), by the General Project in Education Department of Liaoning Province (No. L2014379), by the Career Development Program for Young Teachers in Shenyang Pharmaceutical University, by the National Nature Science Foundation of China (No. 81502993).

Compliance with Ethical standards

Conflict of Interest

No potential conflicts of interest were disclosed by any of the authors.


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Copyright information

© The Pharmaceutical Society of Korea 2015

Authors and Affiliations

  1. 1.School of PharmacyShenyang Pharmaceutical UniversityShenyangChina
  2. 2.GE HealthcareShanghaiChina
  3. 3.Liaoning Institute for Drug ControlShenyangChina

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