Archives of Pharmacal Research

, Volume 38, Issue 7, pp 1281–1298 | Cite as

Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management

  • Shaheed Ur Rehman
  • Min Sun Choi
  • Kevin Choe
  • Hye Hyun Yoo
Review

Abstract

Complementary and alternative therapies are quickly gaining importance because they are perceived to be free of side effects due to their natural origin. However, herbal remedies are complex mixtures of bioactive entities, which may interact with prescription drugs through pharmacokinetic or pharmacodynamic mechanisms and sometimes result in life-threatening consequences. In particular, diabetes patients are often treated with multiple medications due to different comorbidities, and such patients use antidiabetic medications for their entire lives; thus, it is important to make the public aware of herb interactions with antidiabetic drugs. In this paper, we summarize the reports available on the interaction of herbal remedies with oral hypoglycemic agents and describe mechanisms, preclinical or clinical evidence, importance, and management strategies.

Keywords

Herb–drug interaction Antidiabetics Mechanism Evidence Management 

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Copyright information

© The Pharmaceutical Society of Korea 2014

Authors and Affiliations

  • Shaheed Ur Rehman
    • 1
  • Min Sun Choi
    • 1
  • Kevin Choe
    • 1
  • Hye Hyun Yoo
    • 1
  1. 1.Institute of Pharmaceutical Science and Technology and College of PharmacyHanyang UniversityAnsanRepublic of Korea

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