Extracellular stability of nanoparticulate drug carriers
Nanoparticulate (NP) drug carrier systems are attractive vehicles for selective drug delivery to solid tumors. Ideally, NPs should evade clearance by the reticuloendothelial system while maintaining the ability to interact with tumor cells and facilitate cellular uptake. Great effort has been made to fulfill these design criteria, yielding various types of functionalized NPs. Another important consideration in NP design is the physical and functional stability during circulation, which, if ignored, can significantly undermine the promise of intelligently designed NP drug carriers. This commentary reviews several NP examples with stability issues and their consequences, ending in a discussion of experimental methods for reliable prediction of NP stability.
KeywordsNanomedicine Nanoparticles Drug delivery Stability Sensitivity
This work was supported by NSF DMR-1056997, a Grant from the Lilly Endowment, Inc. to College of Pharmacy, Purdue University, and Intramural Research Program (Global RNAi Carrier Initiative) of Korea Institute of Science and Technology. This study was also partly supported by the NIH/NCRR-Indiana Clinical and Translational Sciences Institute Pre-doctoral Fellowship (TL1 RR025759, PI: A. Shekhar) to KCL.
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