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Archives of Pharmacal Research

, Volume 37, Issue 7, pp 845–851 | Cite as

Phenolic compounds with IL-6 inhibitory activity from Aster yomena

  • A Ryun Kim
  • Qinglong Jin
  • Hong-Guang Jin
  • Hae Ju Ko
  • Eun-Rhan Woo
Research Article

Abstract

A new biflavonoid, named asteryomenin (1), as well as six known phenolic compounds, esculetin (2), 4-O-β-d-glucopyranoside-3-hydroxy methyl benzoate (3), caffeic acid (4), isoquercitrin (5), isorhamnetin-3-O-glucoside (6), and apigenin (7) were isolated from the aerial parts of Aster yomena. The structures of compounds (1–7) were identified based on 1D and 2D NMR, including 1H–1H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Compounds 2–7 were isolated from this plant for the first time. For these isolates, the inhibitory activity of IL-6 production in the TNF-α stimulated MG-63 cell was examined. Among these isolates, compounds 4 and 7 appeared to have potent inhibitory activity of IL-6 production in the TNF-α stimulated MG-63 cell, while compounds 1–3 and 5–6 showed moderate activity.

Keywords

Aster yomena Makino Asteraceae Asteryomenin IL-6 inhibitory activity 

Notes

Acknowledgments

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012R1A1A3005531).

Supplementary material

12272_2013_236_MOESM1_ESM.doc (1.5 mb)
Supplementary material 1 (DOC 1575 kb)

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Copyright information

© The Pharmaceutical Society of Korea 2013

Authors and Affiliations

  • A Ryun Kim
    • 1
  • Qinglong Jin
    • 1
  • Hong-Guang Jin
    • 1
  • Hae Ju Ko
    • 1
  • Eun-Rhan Woo
    • 1
  1. 1.College of PharmacyChosun UniversityGwangjuRepublic of Korea

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