Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans
Abstract
Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.
Keywords
Myristica fragrans Vietnamese nutmeg Meso-dihydroguaiaretic acid Cytotoxicity Antitumor activityNotes
Acknowledgments
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 106.99.99.09. This research was also supported by a Grant from the Global R&D Center (GRDC) Program through the NRF funded by the MEST and by a Grant from the KRIBB Research Initiative Program. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2009-0093815).
References
- Bich, D.H. 2004. Medicinal plants and animals of Vietnam, vol. II, 472–476. Hanoi: Publishing House of Science and Technology.Google Scholar
- Braz Fo, R., N.G. de Carvalho, and O.R. Gottlieb. 1984. XVIII: eperudiendiol, glycerides and neolignans from fruits of Osteophloeum platyspermum. Planta Medica 50: 53–55.CrossRefGoogle Scholar
- Davis, R.A., E.C. Barnes, J. Longden, V.M. Avery, and P.C. Healy. 2009. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum. Bioorganic and Medicinal Chemistry 17: 1387–1392.PubMedCrossRefGoogle Scholar
- Hattori, M., S. Hada, Y. Kawata, Y. Tezuka, T. Kikuchi, and T. Namba. 1987a. New 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignans from the aril of Myristica fragrans. Chemical and Pharmaceutical Bulletin 35: 3315–3332.CrossRefGoogle Scholar
- Hattori, M., S. Hada, Y.Z. Shu, N. Kakiuchi, and T. Namba. 1987b. New acyclic bis-phenylpropanoids from the aril of Myristica fragrans. Chemical and Pharmaceutical Bulletin 35: 668–674.CrossRefGoogle Scholar
- Li, F., and X.W. Yang. 2007. Biotransformation of myrislignan by rat liver microsomes in vitro. Phytochemistry 69: 765–771.PubMedCrossRefGoogle Scholar
- Loi, D.T. 1999. Vietnamese medicinal plants and remedies, 406–408. Hanoi: Medicinal Publishing House.Google Scholar
- Nonaka, Y., H. Shibata, M. Nakai, H. Kurihara, H. Ishibashi, Y. Kiso, T. Tanaka, H. Yamaguchi, and S. Abe. 2006. Anti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing mice. Bioscience, Biotechnology, and Biochemistry 70: 2028–2034.PubMedCrossRefGoogle Scholar
- Paul S, Hwang JK, Kim HY, Jeon WK, Chung C, and Han JS. 2013. Multiple biological properties of macelignan and its pharmacological implications. Archives of Pharmacal Research 36: 264–272.Google Scholar
- Woo, W.S., H.S. Kuk, H. Wagner, and H. Lotter. 1987. The structure of macelignan from Myristica fragrans. Phytochemistry 26: 1542–1543.CrossRefGoogle Scholar
- Yang, S., M. Na, J.P. Jang, K.A. Kim, B.Y. Kim, N.J. Sung, W.K. Oh, and J.S. Ahn. 2006. Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans. Phytotherapy Research 20: 680–682.PubMedCrossRefGoogle Scholar
- Zhao, Z.Z., and P.G. Xiao. 2010. Encyclopedia of Medicinal Plants, vol. 4, 332–336. Shanghai: World Publishing Corporation.Google Scholar