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Archives of Pharmacal Research

, Volume 36, Issue 5, pp 626–633 | Cite as

Effect of sinapic acid against carbon tetrachloride-induced acute hepatic injury in rats

  • Dong-Su Shin
  • Kung Wook Kim
  • Hae Young Chung
  • Sik Yoon
  • Jeon-Ok Moon
Research Article

Abstract

Acute hepatic inflammation is regarded as a hallmark of early stage fibrosis, which can progress to extensive fibrosis and cirrhosis. Sinapic acid is a phenylpropanoid compound that is abundant in cereals, nuts, oil seeds, and berries and has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the anti-inflammatory effect of sinapic acid in carbon tetrachloride (CCl4)-induced acute hepatic injury in rats. Sinapic acid was administered orally (10 or 20 mg/kg) to rats at 30 min and 16 h before CCl4 intoxication. Sinapic acid treatment of rats reduced CCl4-induced abnormalities in liver histology, serum alanine transaminase and aspartate transaminase activities, and liver malondialdehyde levels. In addition, sinapic acid treatment significantly attenuated the CCl4-induced production of inflammatory mediators, including tumor necrosis factor-alpha and interleukin-1β mRNA levels, and increased the expression of nuclear factor-kappa B (NF-κB p65). Sinapic acid exhibited strong free radical scavenging activity in vitro. Thus, sinapic acid protected the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinapic acid may thus have potential as a therapeutic agent for suppressing hepatic inflammation.

Keywords

Sinapic acid Hepatoprotective effect Antifibrogenic effect Antioxidant effect Liver fibrosis Hepatic stellate cell NF-κB p65 TNF-α IL-1β 

Notes

Acknowledgments

This work was supported by a 2-Year Research Grant of Pusan National University.

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Copyright information

© The Pharmaceutical Society of Korea 2013

Authors and Affiliations

  • Dong-Su Shin
    • 1
    • 3
  • Kung Wook Kim
    • 1
  • Hae Young Chung
    • 1
  • Sik Yoon
    • 2
  • Jeon-Ok Moon
    • 1
  1. 1.College of PharmacyPusan National UniversityBusanKorea
  2. 2.Department of Anatomy, College of MedicinePusan National UniversityBusanKorea
  3. 3.Animal, Plant, and Fisheries Quarantine and Inspection AgencyBusanKorea

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