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Archives of Pharmacal Research

, Volume 36, Issue 3, pp 322–326 | Cite as

Three new nor-dammarane triterpenoids from Dysoxylum hainanense with particular cytotoxicity against glioma cell line

  • Peng CaoEmail author
  • Guobiao Liang
  • Xu Gao
  • Xiaogang Wang
  • Zhiqing Li
Research Article

Abstract

Three new nor-dammarane triterpenoids, 12β-O-acetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (1), 12β,28-O-diacetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (2), 12β-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanran (3), together with one known compound, 12β-O-acetyl-15α,28-dihydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (4), were isolated from the 95 % EtOH extract of Dysoxylum hainanense. The structures of the new compounds were elucidated by spectral methods. All the triterpenoids were in vitro evaluated for their cytotoxic activities against four tumor cell lines (BGC-823, U251, HepG2 and SGC-7901). All the three nor-dammarane triterpenoids exhibited particular significant cytotoxic activities against glioma cell line.

Keywords

Dysoxylum hainanense Meliaceae Nor-dammarane triterpenoids Cytotoxicity 

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Copyright information

© The Pharmaceutical Society of Korea 2013

Authors and Affiliations

  • Peng Cao
    • 1
    Email author
  • Guobiao Liang
    • 1
  • Xu Gao
    • 1
  • Xiaogang Wang
    • 1
  • Zhiqing Li
    • 1
  1. 1.Department of NeurosurgeryShenyang Northern HospitalShenhe district, ShenyangPeople’s Republic of China

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