Archives of Pharmacal Research

, Volume 36, Issue 2, pp 208–222 | Cite as

Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes

  • Jongsoon LeeEmail author


It has been increasingly accepted that chronic subacute inflammation plays an important role in the development of insulin resistance and type 2 Diabetes in animals and humans. Particularly supporting this is that suppression of systemic inflammation in type 2 Diabetes improves glycemic control; this also points to a new potential therapeutic target for the treatment of type 2 Diabetes. Recent studies strongly suggest that obesity-induced inflammation is mainly mediated by tissue resident immune cells, with particular attention being focused on adipose tissue macrophages (ATMs). This review delineates the current progress made in understanding obesity-induced inflammation and the roles ATMs play in this process.


Adipose tissue macrophage (ATM) Insulin resistance Obesity Inflammation 



The author was supported by grants from the American Diabetes Association (RA 110BS97), Pilot and Feasibility awards from the Boston Obesity Nutrition Research Center (DK046200, NIDDK) and NIH/NIDDK (DK80380).


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© The Pharmaceutical Society of Korea 2013

Authors and Affiliations

  1. 1.Joslin Diabetes CenterHarvard Medical SchoolBostonUSA

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