Archives of Pharmacal Research

, Volume 35, Issue 11, pp 1979–1988

Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells

  • Se-Woong Oh
  • Jung Bok Lee
  • Bora Kim
  • Sejin Jeon
  • Min-Kyoung Kim
  • Ki-Hoan Nam
  • Jong-Ryul Ha
  • Mickie Bhatia
  • Goo Taeg Oh
  • Dae-Yong Kim
Research Article Drug Action

DOI: 10.1007/s12272-012-1115-6

Cite this article as:
Oh, SW., Lee, J.B., Kim, B. et al. Arch. Pharm. Res. (2012) 35: 1979. doi:10.1007/s12272-012-1115-6

Abstract

Embryonic stem (ES) cells may be used as an alternative source of functionally intact cardiomyocytes for ischemic heart disease. Several natural and synthetic small molecules have been identified as useful tools for controlling and manipulating stem cell renewal and differentiation. Currently, there is an urgent requirement for novel small molecules that specifically induce differentiation of stem cells into cardiomyocytes. To identify compounds that promote cardiomyogenesis of stem cells, cell-based screening of a peptidomimetic small-molecule library was carried out. A series of β-turn peptidomimetic compounds, including CW209E, increased the expression of α-MHC promoter-driven enhanced green fluorescent protein (EGFP) and ratio of beating embryoid bodies (EBs) without inducing cytotoxicity in mouse embryonic stem cells. CW209E also increased the number of beating EBs in human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Thus, this chemical compound should be useful for elucidation of the molecular pathway of cardiogenesis and generation of cardiomyocytes ex vivo, which can be further applied for experimental or clinical cell therapy for ischemic heart diseases.

Key words

Embryonic stem cells Cardiogenesis Peptidomimetic compounds Ischemic heart disease 

Copyright information

© The Pharmaceutical Society of Korea and Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Se-Woong Oh
    • 1
  • Jung Bok Lee
    • 2
  • Bora Kim
    • 3
  • Sejin Jeon
    • 3
  • Min-Kyoung Kim
    • 1
  • Ki-Hoan Nam
    • 4
  • Jong-Ryul Ha
    • 1
  • Mickie Bhatia
    • 2
  • Goo Taeg Oh
    • 3
  • Dae-Yong Kim
    • 5
    • 6
  1. 1.Central Research InstituteJW Pharmaceutical CorporationHwaseongKorea
  2. 2.Stem Cell and Cancer Research InstituteMcMaster UniversityHamiltonCanada
  3. 3.Lab. of Cardiovascular Genomics, Division of Life and Pharmaceutical ScienceEwha Womans UniversitySeoulKorea
  4. 4.Bio-Evaluation CenterKRIBBCheongchungbuk-DoKorea
  5. 5.Department of Veterinary Pathology and Research Institute for Veterinary Science, College of Veterinary MedicineSeoul National UniversitySeoulKorea
  6. 6.Department of Veterinary Pathology, College of Veterinary MedicineSeoul National UniversitySeoulKorea

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