Archives of Pharmacal Research

, Volume 35, Issue 10, pp 1749–1756

Bioactive anthraquinones from endophytic fungus Aspergillus versicolor isolated from red sea algae

  • Usama W. Hawas
  • Ahmed Atef El-Beih
  • Ali M. El-Halawany
Research Article Drug Design and Discovery

DOI: 10.1007/s12272-012-1006-x

Cite this article as:
Hawas, U.W., El-Beih, A.A. & El-Halawany, A.M. Arch. Pharm. Res. (2012) 35: 1749. doi:10.1007/s12272-012-1006-x


The marine fungus Aspergillus versicolor was isolated from the inner tissue of the Red Sea green alga Halimeda opuntia. The fungus was identified by its morphology and 18s rDNA. Cultivation of this fungal strain led to a new metabolite named isorhodoptilometrin-1-methyl ether (1) along with the known compounds emodin (2), 1-methyl emodin (3), evariquinone (4), 7-hydroxyemodin 6,8-methyl ether (5), siderin (6), arugosin C (7), and variculanol (8). The structures were elucidated on the basis of NMR spectroscopic analysis and mass spectrometry. The biological properties of ethyl acetate extract and compounds 1–3 and 6–8 were explored for antimicrobial activity, anti-cancer activity and inhibition of Hepatitis C virus (HCV) protease.

Key words

Halimeda opuntia Aspergillus versicolor Anthraquinones HCV N3/4A protease 

Copyright information

© The Pharmaceutical Society of Korea and Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Usama W. Hawas
    • 1
  • Ahmed Atef El-Beih
    • 2
  • Ali M. El-Halawany
    • 3
  1. 1.Phytochemistry and Plant Systematic DepartmentNational Research CentreDokki, CairoEgypt
  2. 2.Chemistry of Natural and Microbial Products DepartmentNational Research CentreDokki, CairoEgypt
  3. 3.Department of Pharmacognosy, Faculty of PharmacyCairo UniversityCairoEgypt

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