Flavonol triglycoside and investigation of the antioxidant and cell stimulating activities of Annona muricata Linn.
- 653 Downloads
Chemical investigation on leaves of Annona muricata resulted in the isolation of the flavonol triglycoside, quercetin 3-O-α-rhamnosyl-(1″″ → 6″)-β-sophoroside, together with twelve known phenolics. The structures of these compounds were established by 1D- and 2D-nuclear magnetic resonance spectroscopic techniques and mass spectrometry data. The in vitro antioxidant studies of the investigated aqueous ethanol extract and its column fractions were accomplished using the oxygen radical absorbance capacity (ORAC) method. A stimulating effect on HaCaT human keratinocytes by the leaf extract was also assessed. Il-6 production after UV irradiation was not influenced by A. muricata leaf extract.
Key wordsAnnonaceae Annona muricata Quercetin 3-O-rhamnosylsophoroside Antioxidant UV protection
Unable to display preview. Download preview PDF.
- Brever, O., Medicinal plants in tropical West Africa. Cambridge University Press, Cambridge, UK (1986).Google Scholar
- Lindequist, U., Wende, K., Harms, M., Witt, S., Poerksen, J., and Jülich, W. D., Biological and chemical investigations of Ganoderma pfeifferi and possible application of this new medicinal mushroom in cosmetics Conference Proceedings, 5th International Medicinal Mushroom Conference, Nantong, China, September, 615–622 (2009).Google Scholar
- Lucas-Abellán, C., Mercader-Ros, M. T., Zafrilla, M. P., Fortea, M. I., Gabaldón, J. A., and Núñez-Delicado, E., ORAC-fluorescein assay to determine the oxygen radical absorbance capacity of resveratrol complexed in cyclodextrins. J. Agric. Food Chem., 56, 2254–2259 (2008).PubMedCrossRefGoogle Scholar
- Mabry, T. J., Markham, K. R., and Thomas, M. B., The Systematic Identification of Flavonoids. Springer, Heidelberg, (1970).Google Scholar
- Markham, K. R. and Chari, V. M., The Flavonoids: Advances in Research, ed. Harborn, J. B. and Mabry, T. J., Chapman and Hall, London, Chap. 2, (1982).Google Scholar
- Yuan, S. S., Chang, H. L., Chen, H. W., Yeh, Y. T., Kao, Y. H., Lin, K. H., Wu, Y. C., and Su, J. H., Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway. Life Sci., 72, 2853–2861 (2003).PubMedCrossRefGoogle Scholar