Archives of Pharmacal Research

, Volume 35, Issue 2, pp 197–200

Multi-targeted hybrids based on HDAC inhibitors for anti-cancer drug discovery

Report on Investigational Drugs

DOI: 10.1007/s12272-012-0221-9

Cite this article as:
Seo, SY. Arch. Pharm. Res. (2012) 35: 197. doi:10.1007/s12272-012-0221-9


Multi-targeted hybrids combine two drugs in a single molecule to have greater medicinal effects than its individual components. Recently, a number of anti-cancer drug candidates such as CUDC-101 (Curis) have been designed based on linking properly two selected pharmacophores endowed with activity against different therapeutic targets.

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2012

Authors and Affiliations

  1. 1.College of PharmacyWoosuk UniversityWanjuKorea

Personalised recommendations