Archives of Pharmacal Research

, Volume 34, Issue 10, pp 1593–1598

Anti-inflammatory activity on LPS-stimulated dendritic cells of lupanetype triterpenoids from the leaves of Acanthopanax koreanum

  • Nguyen Xuan Nhiem
  • Phan Van Kiem
  • Chau Van Minh
  • Bui Huu Tai
  • Tran Hong Quang
  • Kwang Su Soung
  • Jung-Eun Koo
  • Young-Sang Koh
  • Young Ho Kim
Research Articles Drug Design and Discovery

Abstract

Acanthopanax koreanum is well known herb in traditional Korean, Chinese, and Japanese anti-inflammatory action without any adverse effects. In the current study, we investigated the inhibitory effects of isolated compounds 1–13 from the leaves of A. koreanum on the lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrowderived dendritic cells. Of these lupane-type triterpenoids, 1 exhibited particularly high inhibitory effect on lipopolysaccharide-stimulated TNF-α, IL-6, and IL-12 production with the values ranging from 45.0 to 84.5% at a concentration of 50 μM. These results warrant further studies concerning the potential anti-inflammatory benefits of medicinal foods containing the leaves of A. koreanum.

Keywords

Acanthopanax koreanum Araliaceae Lupane-triterpenoids TNF-α IL-6 IL-12 LPS-stimulated pro-inflammatory cytokine 

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Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  • Nguyen Xuan Nhiem
    • 1
    • 2
  • Phan Van Kiem
    • 2
  • Chau Van Minh
    • 2
  • Bui Huu Tai
    • 1
    • 2
  • Tran Hong Quang
    • 1
    • 2
  • Kwang Su Soung
    • 3
  • Jung-Eun Koo
    • 4
  • Young-Sang Koh
    • 4
  • Young Ho Kim
    • 1
  1. 1.College of PharmacyChungnam National UniversityDaejeonKorea
  2. 2.Institute of Marine BiochemistryVietnam Academy of Science and Technology (VAST)Caugiay, HanoiVietnam
  3. 3.Chungcheongnam-doKorea
  4. 4.School of Medicine and Brain Korea 21 ProgramJeju National UniversityJejuKorea

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