Archives of Pharmacal Research

, Volume 34, Issue 6, pp 919–929 | Cite as

An investigation of formulation factors affecting feasibility of alginate-chitosan microparticles for oral delivery of naproxen

  • Bojan Čalija
  • Nebojsa Cekić
  • Snežana Savić
  • Danina Krajišnik
  • Rolf Daniels
  • Jela Milić
Research Articles Drug Development


In the present work we investigated the feasibility of chitosan treated Ca-alginate microparticles for delivery of naproxen in lower parts of GIT and evaluated influence of formulation factors on their physicochemical characteristics and drug release profiles. Investigated factors were drug/polymer ratio, chitosan molecular weight, chitosan concentration in hardening medium, and hardening time. Sixteen microparticle formulations were prepared utilizing 24 full factorial design (each factor was varied at two levels). Microparticles size varied between 262.3 ± 14.9 and 358.4 ± 21.7 μm with slightly deformed spherical shape. Low naproxen solubility and rapid reaction of ionotropic gelation resulted in high encapsulation efficiency (> 75.19%). Under conditions mimicking those in the stomach, after two hours, less than 6.18% of naproxen was released. Significant influence of all investigated factors on drug release rate was observed in simulated small intestinal fluid. Furthermore, experimental design analysis revealed that chitosan molecular weight and its concentration had the most pronounced effect on naproxen release. Release data kinetics indicated predominant influence of a pH-dependent relaxation mechanism on drug release from microparticles.

Key words

Naproxen Alginate-chitosan microparticles Experimental design Sustained release 


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Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  • Bojan Čalija
    • 1
  • Nebojsa Cekić
    • 2
  • Snežana Savić
    • 1
  • Danina Krajišnik
    • 1
  • Rolf Daniels
    • 3
  • Jela Milić
    • 1
  1. 1.Department of Pharmaceutical Technology, Faculty of PharmacyUniversity of BelgradeBelgradeSerbia
  2. 2.DCP HemigalR&D SectorLeskovacSerbia
  3. 3.Department of Pharmaceutical TechnologyUniversity of TubingenTubingenGermany

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