Archives of Pharmacal Research

, Volume 33, Issue 1, pp 5–15

An efficient synthesis and antioxidant properties of novel imino and amino derivatives of 4-hydroxy coumarins

  • Nenad Vukovic
  • Slobodan Sukdolak
  • Slavica Solujic
  • Neda Niciforovic
Research Articles Drug Design

DOI: 10.1007/s12272-010-2220-z

Cite this article as:
Vukovic, N., Sukdolak, S., Solujic, S. et al. Arch. Pharm. Res. (2010) 33: 5. doi:10.1007/s12272-010-2220-z

Abstract

Series of imino and amino derivatives of 4-hydroxy coumarins were synthesized via conventional and microwave promoted procedure and evaluated for antioxidant potential through different in vitro models such as (DPPH) free radical scavenging activity, linoleic acid emulsion model system, reducing power assay and phosphomolybdenum method. All prepared compounds possess good antioxidant activity and among them p-nitro-phenyl derivative 6c with IC50 at 25.9 μM possesses radical scavenging activity which is comparable to standard BHT, while the best reducing power was observed in a case of benzyl amino compound 8c (RP50 255.6 μM). Also, observed data indicated that compounds may serve as inhibitors of lipid peroxidation process.

Key words

4-Hydroxy coumarin Imines Amines Antioxidant activity 

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  • Nenad Vukovic
    • 1
  • Slobodan Sukdolak
    • 1
  • Slavica Solujic
    • 1
  • Neda Niciforovic
    • 1
  1. 1.Faculty of Science, Department of Chemistry, Laboratory for BiochemistryUniversity of KragujevacKragujevacSerbia

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