A new triterpene and an antiarrhythmic liriodendrin from Pittosporum brevicalyx
- 202 Downloads
A new triterpene, 21-O-senecioyl-R1-barrigenol (1) and 13 known compounds were isolated from the ethanol extracts of the leaves and bark of Pittosporum brevicalyx (Oliv.) Gagnep. Their structures were elucidated based on spectral data. The antiarrhythmic action of one furofuran lignan, liriodendrin (2), was tested on a model of CaCl2-induced arrhythmia and compared with the effect of verapamil. The prophylactic administration of liriodendrin (2) was effective in prolonging latency of arrhythmia and reducing the occurrence of ventricular fibrillation from 75% to 25%. The overall mortality rate was significantly reduced by the prophylactic administration of liriodendrin from 87.5% to 25%. The antiarrhythmic effect of liriodendrin (5.0 mg/kg) was similar to that of verapamil (1.05 mg/kg). Thus, liriodendrin may be a potent suppressor of CaCl2-induced arrhythmias.
Key wordsPittosporum brevicalyx Liriodendrin Antiarrhythmic CaCl2-induced arrhythmias
Unable to display preview. Download preview PDF.
- Du, N. S., Ma, C., and Zhang, X., Blood lipid reducing effect of Poacynum hendersonii leaf aqueous extracts and two compounds therein. CHN Patent, 1748723 (2006).Google Scholar
- Institute of Botany, Chinese Academy of Science & Institute of Material Medical, Chinese Academy of Medical Science, Flora Reipublicae Popularis sinicae, Vol. 35, Science Press, Beijing, pp. 1, (1992).Google Scholar
- Institute of Botany, Chinese Academy of Science & Institute of Material Medical, Chinese Academy of Medical Science, Flora Reipublicae Popularis sinicae, Vol. 35, Science Press, Beijing, pp. 32–33 (1992).Google Scholar
- John, A. J., Karunakaran, V. P., George, V., Pradeep, N. S., and Sethuraman, M. G., Constituents and antibacterial activity of the essential oils from the leaves and fruits of Pittosporum viridulum. J. Essent. Oil Res., 19, 591–593 (2007).Google Scholar
- Jolad, S. D., Hoffmann, J. J., Cole, J. R., Tempesta, M. S., and Bates, R. B., Cytotoxic agent from Penstemon deustus (Scrophulariaceae): isolation and stereochemistry of liriodendrin, a symmetrically substituted furofuranoid lignan diglucoside. J. Org. Chem., 45, 1327–1329 (1980).CrossRefGoogle Scholar
- Wu, G. D., Qian, Z. Q., and Dai, J., Experimental study on antituberculous activities of Pittosporum brevicalyx (Oliv.) Gagnep. J. Chin. Antituberculosis. Assoc., 29, 41–43 (2007).Google Scholar
- Xie, T., Liang, J. Y., Liu, J., Wang, M., Wei, X. L., and Yang, C. H., Chemical Study on Artemisia scoparia. J. China Pharm. Univ., 35, 401–403 (2004).Google Scholar
- Yamazaki, T., Shimosaka, S., Sasaki, H., Matsumura, T., Tukiyama, T., and Tokiwa, T., (+)-Syringaresinol-di-O-β-D-glucoside, a phenolic compound from Acanthopanax senticosus Harms, suppresses proinflammatory mediators in SW982 human synovial sarcoma cells by inhibiting activating protein-1 and/or nuclear factor-κB activities. Toxicol. In Vitro, 21, 1530–1537 (2007).CrossRefPubMedGoogle Scholar
- Yang, H. T., Chen, Y. S., Xie, J. M., and Zhao, S. N., Chemical constituents of Pittosporum brevicalyx (Oliv) Gagnep. Huaxue Xuebao, 44, 946–950 (1986).Google Scholar
- Yoshizawa, F., Deyama, T., Takizawa, N., Usmanghani, K., and Ahmad, M., The constituents of Cistanche tubulosa (Schrenk) hook. f. II. Isolation and structures of a new phenylethanoid glycoside and a new neolignan glycoside. Chem. Pharm. Bull., 38, 1927-1930 (1990).Google Scholar
- Zhao, D. L., Shen, D. W., Chi, Y. T., Liu, F., Zou, L. B., and Zhu, H. B., Liriodendrin protects SH-SY5Y cells from dopamine-induced cytotoxicity. J. Chin. Pharm. Sci., 16, 294–299 (2007).Google Scholar