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Archives of Pharmacal Research

, Volume 33, Issue 12, pp 1927–1932 | Cite as

A new triterpene and an antiarrhythmic liriodendrin from Pittosporum brevicalyx

  • Chun Feng
  • Bo-Gang Li
  • Xiao-Ping Gao
  • Hua-Yi Qi
  • Guo-Lin Zhang
Research Articles Drug Discovery and Development

Abstract

A new triterpene, 21-O-senecioyl-R1-barrigenol (1) and 13 known compounds were isolated from the ethanol extracts of the leaves and bark of Pittosporum brevicalyx (Oliv.) Gagnep. Their structures were elucidated based on spectral data. The antiarrhythmic action of one furofuran lignan, liriodendrin (2), was tested on a model of CaCl2-induced arrhythmia and compared with the effect of verapamil. The prophylactic administration of liriodendrin (2) was effective in prolonging latency of arrhythmia and reducing the occurrence of ventricular fibrillation from 75% to 25%. The overall mortality rate was significantly reduced by the prophylactic administration of liriodendrin from 87.5% to 25%. The antiarrhythmic effect of liriodendrin (5.0 mg/kg) was similar to that of verapamil (1.05 mg/kg). Thus, liriodendrin may be a potent suppressor of CaCl2-induced arrhythmias.

Key words

Pittosporum brevicalyx Liriodendrin Antiarrhythmic CaCl2-induced arrhythmias 

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Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  • Chun Feng
    • 1
    • 2
  • Bo-Gang Li
    • 1
  • Xiao-Ping Gao
    • 3
  • Hua-Yi Qi
    • 1
  • Guo-Lin Zhang
    • 1
  1. 1.Chengdu Institute of BiologyChinese Academy of SciencesChengduChina
  2. 2.Graduate School of Chinese Academy of SciencesBeijingChina
  3. 3.Pharmaceutical Institute of Kang Hong Pharmaceutical GroupChengduChina

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