Archives of Pharmacal Research

, Volume 33, Issue 6, pp 925–932

Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats

Research Articles Drug Actions

DOI: 10.1007/s12272-010-0616-4

Cite this article as:
Lee, ES., Shin, MO., Yoon, S. et al. Arch. Pharm. Res. (2010) 33: 925. doi:10.1007/s12272-010-0616-4


Resveratrol, a phytoalexin found in grapes and red wines, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of resveratrol on hepatic injury induced by dimethylnitrosamine (DMN) in rats. Oral administration of resveratrol (20 mg/kg daily for 4 weeks) remarkably prevented the DMN-induced loss in body and liver weight, and inhibited the elevation of serum alanine transaminase, aspartate transaminase, alkaline phosphatase and bilirubin levels. Resveratrol also increased serum albumin and hepatic glutathione levels and reduced the hepatic level of malondialdehyde due to its antioxidant effect. Furthermore, DMN-induced elevation of hydroxyproline content was reduced in the resveratrol treated rats, the result of which was consistent with the reduction in type I collagen mRNA expression and the histological analysis of liver tissue stained with Sirius red. The reduction in hepatic stellate cell activation, as assessed by α-smooth muscle actin staining, and the reduction in transforming growth factor-β1 mRNA expression were associated with resveratrol treatment. In conclusion, resveratrol exhibited in vivo hepatoprotective and antifibrogenic effects against DMN-induced liver injury, suggesting that resveratrol may be useful in the prevention of the development of hepatic fibrosis.

Key words

Resveratrol Hepatoprotective effect Antifibrogenic effect Antioxidant effect Hepatic stellate cell TGF-β1 

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  • Eun-Sil Lee
    • 1
  • Mi-Ok Shin
    • 1
    • 2
  • Sik Yoon
    • 3
  • Jeon-Ok Moon
    • 1
  1. 1.College of PharmacyPusan National UniversityBusanKorea
  2. 2.Department of Food and NutritionSilla UniversityBusanKorea
  3. 3.Department of Anatomy, College of MedicinePusan National UniversityBusanKorea

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