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Archives of Pharmacal Research

, Volume 33, Issue 5, pp 675–680 | Cite as

Biological activity of chemical constituents from Clausena harmandiana

  • Tula Thongthoom
  • Uraiwan Songsiang
  • Chanokbhorn Phaosiri
  • Chavi YenjaiEmail author
Research Articles Drug Discovery and Development

Abstract

The activity guided fractionation of the Clausena harmandiana root extracts led to the isolation of a coumarin, a ferulate, and eight carbazoles. This is the first report of the isolation of compounds 2–4 and 6–10 from this species, and this is the first time 10 was isolated from this genus. Compound 4 showed strong cytotoxicity against NCI-H187 cells with an IC50 value of 1.63 μg/mL. Compound 5 demonstrated strong cytotoxicity against MCF-7 and KB cell lines with IC50 values of 2.21 and 1.74 μg/mL, respectively. Compounds 3 and 4 exhibited moderate cytotoxicity against the MCF-7 cell line, and 8 showed moderate cytotoxicity against NCIH187 and KB cell lines. Compounds 3 and 5 showed antiplasmodial activity with IC50 values of 3.27 and 2.94 μg/mL, respectively.

Key words

Clausena harmandiana Cytotoxicity Antimalaria Anti-TB Antifungal 

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Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  • Tula Thongthoom
    • 1
  • Uraiwan Songsiang
    • 1
  • Chanokbhorn Phaosiri
    • 1
  • Chavi Yenjai
    • 1
    Email author
  1. 1.Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of ScienceKhon Kaen UniversityKhon KaenThailand

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