Archives of Pharmacal Research

, Volume 33, Issue 5, pp 647–654

Antimicrobial activity of new 4,6-disubstituted pyrimidine, pyrazoline, and pyran derivatives

  • Mahmoud M. M. Ramiz
  • Wael A. El-Sayed
  • Asmaa I. El-Tantawy
  • Adel A. -H. Abdel-Rahman
Research Articles Drug Design


A number of new 2,6-didisubstituted pyrimidine, pyrazoline, and pyran derivatives were synthesized starting from their chalcone derivative. The synthesized compounds displayed different degrees of antimicrobial activity against Bscillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes).

Key words

Pyrimidines Pyrazolines Pyrans Antimicrobial activity 


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Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  • Mahmoud M. M. Ramiz
    • 1
  • Wael A. El-Sayed
    • 2
    • 4
  • Asmaa I. El-Tantawy
    • 1
  • Adel A. -H. Abdel-Rahman
    • 3
  1. 1.Department of Physics and Mathematical Engineering, Faculty of Electronic EngineeringMenoufia UniversityMenoufEgypt
  2. 2.Department of PhotochemistryNational Research CentreCairoEgypt
  3. 3.Department of Chemistry, Faculty of ScienceMenoufia UniversityShebin El-KoamEgypt
  4. 4.Department of PhotohemistryNational Research CenterCairoEgypt

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