Archives of Pharmacal Research

, Volume 33, Issue 3, pp 463–468 | Cite as

The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in Morris water maze

  • Mahmoud Hosseini
  • Mosa Al-Reza Hadjzadeh
  • Mohammad Derakhshan
  • Shahrzad Havakhah
  • Fatemeh Behnam Rassouli
  • Hassan Rakhshandeh
  • Fatema Saffarzadeh


Functional consequences of hypothyroidism include impaired learning and memory and inability to produce long-term potentiation (LTP) in hippocampus. Olibanum has been used for variety of therapeutic purposes. In traditional medicine, oilbanum is used to enhance learning and memory. In the present study the effect of olibanum on memory deficit in hypothyroid rats was investigated. Male wistar rats were divided into four groups and treated for 180 days. Group 1 received tap drinking water while in group 2, 0.03% methimazol was added to drinking water. Group 3 and 4 were treated with 0.03% methimazole as well as 100 and 500 mg/kg olibanum respectively. The animals were tested in Morris water maze. The swimming speed was significantly lower and the distance and time latency were higher in group 2 compared with group 1. In groups 3 and 4 the swimming speed was significantly higher while, the length of the swim path and time latency were significantly lower in comparison with group 2. It is concluded that methimazole-induced hypothyroidism impairs learning and memory in adult rats which could be prevented by using olibanum.

Key words

Boswellia serrata Hypothyroidism Learning Memory Olibanum 


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Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  • Mahmoud Hosseini
    • 1
    • 5
  • Mosa Al-Reza Hadjzadeh
    • 1
  • Mohammad Derakhshan
    • 2
  • Shahrzad Havakhah
    • 1
  • Fatemeh Behnam Rassouli
    • 3
  • Hassan Rakhshandeh
    • 4
  • Fatema Saffarzadeh
    • 1
  1. 1.Department of Physiology, School of MedicineMashhad University of Medical Sciences (MUMS)MashhadIran
  2. 2.Department of Clinical Microbiology and Virology in Ghaem Medical Center (Hospital) and Buali Research Institute Mashhad University of Medical Sciences (MUMS)MashhadIran
  3. 3.Department of Biology, Faculty of SciencesFerdowsi University of MashhadMashhadIran
  4. 4.Department of Pharmacology and Pharmacological Research Center of Medicinal PlantsMashhad University of Medical Sciences (MUMS)MashhadIran
  5. 5.Department of Physiology, Medical SchoolMashhad University of Medical SciencesMashhadIran

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