Archives of Pharmacal Research

, Volume 33, Issue 3, pp 369–373 | Cite as

Two acetylated megastigmane glycosides from the leaves of Ilex paraguariensis

  • Guang-Hua Xu
  • Young-Hee Kim
  • Soo-Jin Choo
  • In-Ja Ryoo
  • Jae-Kuk Yoo
  • Jong-Seog Ahn
  • Ick-Dong Yoo
Article

Abstract

Two acetylated megastigmane glycosides, matenosides A (1) and B (2), have been isolated from the MeOH extract of Ilex paraguariensis leaves, and their structures were elucidated on the basis of spectroscopic analysis. Compounds 1 and 2 exhibited human neutrophil elastase (HNE) inhibitory activity with IC50 values of 50.4 μM and 11.1 μM, respectively.

Key words

Megastigmane glycosides Ilex paraguariensis Matenosides A and B 

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Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  • Guang-Hua Xu
    • 1
    • 3
  • Young-Hee Kim
    • 1
  • Soo-Jin Choo
    • 1
  • In-Ja Ryoo
    • 1
  • Jae-Kuk Yoo
    • 2
  • Jong-Seog Ahn
    • 1
  • Ick-Dong Yoo
    • 1
  1. 1.Korea Research Institute of Bioscience and BiotechnologyDaejeonKorea
  2. 2.Han Kook Shin YakYangchonmyeon, Nonsan, ChungnamKorea
  3. 3.College of PharmacyYanbian UniversityYanji, JilinChina

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