Archives of Pharmacal Research

, Volume 32, Issue 4, pp 565–573 | Cite as

Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks

  • Qiu-hai Qian
  • Wang Yue
  • Yao-xia Wang
  • Zhi-hong Yang
  • Zhan-tao Liu
  • Wen-hui Chen
Article

Abstract

Objective

To investigate the antiemetic effect of gingerol and its multi-targets effective mechanism on 5-hydroxytryptamine (5-HT), dopamine (DA) and substance P (SP). The antiemetic effect of gingerol was investigated on a vomiting model of mink induced by cisplatin (7.5 mg · kg−1, i.p.) in 6 h observation. The levels of 5-HT, DA and distribution of substance P in the area postrema and ileum were measured by high performance liquid chromatography (HPLC) and immunohistochemistry respectively. The frequency of cisplatin induced retching and vomiting was significantly reduced by pretreatment with gingerol in a dose-dependent manner (P<0.05). Cisplatin produced a significant increase in 5-HT and DA levels in the area postrema and ileum of minks (P<0.05), and this increase was significantly inhibited by gingerol in a dose-dependent manner (P<0.05). Substance P-immunoreactive was mainly situated in the mucosa and submucosa of ileum as well as in the neurons of area postrema, and gingerol markedly suppressed the increase immunoreactivity of substance P induced by cisplatin in a dose-dependent manner (P<0.05). Gingerol has good activity against cisplatin-induced emesis in minks possibly by inhibiting central or peripheral increase of 5-HT, DA and substance P.

Key words

Gingerol Vomiting Mink Cisplatin 5-HT Dopamine Substance P 

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Copyright information

© The Pharmaceutical Society of Korea 2009

Authors and Affiliations

  • Qiu-hai Qian
    • 1
    • 2
  • Wang Yue
    • 1
  • Yao-xia Wang
    • 1
  • Zhi-hong Yang
    • 1
  • Zhan-tao Liu
    • 1
  • Wen-hui Chen
    • 2
  1. 1.Pharmic DepartmentMedical College of Qingdao UniversityQingdao, ShandongChina
  2. 2.Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan, ShandongChina

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