Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks
- 197 Downloads
To investigate the antiemetic effect of gingerol and its multi-targets effective mechanism on 5-hydroxytryptamine (5-HT), dopamine (DA) and substance P (SP). The antiemetic effect of gingerol was investigated on a vomiting model of mink induced by cisplatin (7.5 mg · kg−1, i.p.) in 6 h observation. The levels of 5-HT, DA and distribution of substance P in the area postrema and ileum were measured by high performance liquid chromatography (HPLC) and immunohistochemistry respectively. The frequency of cisplatin induced retching and vomiting was significantly reduced by pretreatment with gingerol in a dose-dependent manner (P<0.05). Cisplatin produced a significant increase in 5-HT and DA levels in the area postrema and ileum of minks (P<0.05), and this increase was significantly inhibited by gingerol in a dose-dependent manner (P<0.05). Substance P-immunoreactive was mainly situated in the mucosa and submucosa of ileum as well as in the neurons of area postrema, and gingerol markedly suppressed the increase immunoreactivity of substance P induced by cisplatin in a dose-dependent manner (P<0.05). Gingerol has good activity against cisplatin-induced emesis in minks possibly by inhibiting central or peripheral increase of 5-HT, DA and substance P.
Key wordsGingerol Vomiting Mink Cisplatin 5-HT Dopamine Substance P
Unable to display preview. Download preview PDF.
- Andrews, P. L. R. and Rudd, J. A., The role of tachykinins and the tachykinin receptor in nausea and emesis. In Holzer, P. (Eds.), Handbook of Experimental Pharmacology. Springer-Verlag Berlin Heidelberg, Germany, pp. 359–440 (2004).Google Scholar
- Hesketh, P. J., Van Belle, S., Aapro, M., Tattersall, F. D., Naylor, R. J., Hargreaves, R., Carides, A. D., Evans, J. K., and Horgan, K. J., Differential involvement of neurotransmitters through the time course of cisplatin-induced emesis as revealed by therapy with specific receptor antagonists. Eur. J. Cancer, 39, 1074–1080 (2003).PubMedCrossRefGoogle Scholar
- Hickok, T. J. and Morrow, G. R., A biobehavioral model of patientreported nausea: implications for clinical practise. Adv. Med. Psychother, 6, 227 (1993).Google Scholar
- Jiang, S. Z., Mi, S. Z., and Wang, N. S., Survey of chemical constituents of gingerol. Traditional Chinese Drug Research & Clinical Pharmacology (in Chinese), 17, 386–389 (2006).Google Scholar
- Leksowski, K., Peryga, P., and Szyca, R., Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study. Surg Endosc, 20, 878–882 (2006).PubMedCrossRefGoogle Scholar
- Minami, M., Endo, T., and Hamaue, N. et al., Serotonin and anticancer drug-induced emesis. Surg Endosc, 124, 491–507 (2004).Google Scholar
- Rudd, J. A. and Andrews, P. L. R., Mechanisms of acute, delayed, and anticipatory emesis induced by anticancer therapies, In P.J. Hesketh (Eds.), Management of Nausea and Vomiting in Cancer and Cancer Treatment, Jones and Barlett Publishers, Inc., USA, pp 15–66 (2004).Google Scholar
- Pongrojpaw, D. et al., The efficacy of ginger in prevention of post-operative nausea and vomiting after outpatient gynecological laparoscopy. J. Med. Assoc. Thai, 3, 244–250 (2003).Google Scholar
- Rudd, J. A. and Andrews, P. L. R., Mechanisms of acute, delayed and anticipatory vomiting in cancer and cancer treatment. In Hesketh, P. (Eds.), Management of Nausea and Vomiting in Cancer and Cancer Treatment. Jones and Barlett Publishers Inc., New York, pp 15–66 (2004).Google Scholar
- Zhao, D.-x., Yang, Z.-h., Li, M., Xue, M., and Yue, W., Anti-emetic effects of ginger on a nausea model of mink. Chinese Pharmaceutical Affairs (in Chinese), 10, 601–604 (2006).Google Scholar