Archives of Pharmacal Research

, Volume 32, Issue 4, pp 515–520 | Cite as

New anthracene glycosides from Rhodomyrtus tomentosa stimulate osteoblastic differentiation of MC3T3-E1 cells

  • Nguyen Huu Tung
  • Yan Ding
  • Eun Mi Choi
  • Phan Van Kiem
  • Chau Van Minh
  • Young Ho Kim
Article

Abstract

Two new anthracene glycosides (1, 2) were isolated from aerial parts of Rhodomyrtus tomentosa, along with three known compounds (3–5). The structures of two new compounds were established to be 4,8,9,10-tetrahydroxy-2,3,7-trimethoxyanthracene-6-O-β-D-glucopyranoside (1) and 2,4,7,8,9,10-hexahydroxy-3-methoxyanthracene-6-O-α-L-rhamnopyranoside (2) based on spectroscopic and chemical methods. Among them, compound 1, 2, and 5 significantly (P<0.05) increased the alkaline phosphatase activity, collagen synthesis, and mineralization of the nodules of MC3T3-E1 osteoblastic cells compared to those of the control, respectively.

Key words

Rhodomyrtus tomentosa Myrtaceae Anthracene glycoside Osteoblast MC3T3-E1 cells 

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Copyright information

© The Pharmaceutical Society of Korea 2009

Authors and Affiliations

  • Nguyen Huu Tung
    • 1
    • 2
  • Yan Ding
    • 1
  • Eun Mi Choi
    • 1
  • Phan Van Kiem
    • 2
  • Chau Van Minh
    • 2
  • Young Ho Kim
    • 1
  1. 1.College of PharmacyChungnam National UniversityDaejeonKorea
  2. 2.Institute of Natural Products ChemistryVietnam Academy of Science and TechnologyHanoiVietnam

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