New anthracene glycosides from Rhodomyrtus tomentosa stimulate osteoblastic differentiation of MC3T3-E1 cells
- 281 Downloads
Two new anthracene glycosides (1, 2) were isolated from aerial parts of Rhodomyrtus tomentosa, along with three known compounds (3–5). The structures of two new compounds were established to be 4,8,9,10-tetrahydroxy-2,3,7-trimethoxyanthracene-6-O-β-D-glucopyranoside (1) and 2,4,7,8,9,10-hexahydroxy-3-methoxyanthracene-6-O-α-L-rhamnopyranoside (2) based on spectroscopic and chemical methods. Among them, compound 1, 2, and 5 significantly (P<0.05) increased the alkaline phosphatase activity, collagen synthesis, and mineralization of the nodules of MC3T3-E1 osteoblastic cells compared to those of the control, respectively.
Key wordsRhodomyrtus tomentosa Myrtaceae Anthracene glycoside Osteoblast MC3T3-E1 cells
Unable to display preview. Download preview PDF.
- Agrawal, P. K., Carbon-13 NMR of flavonoids. Elsevier Science Publishers, New York, 1989.Google Scholar
- Ho, P. K., An illustrated flora of Vietnam. Tre Publishing House, Hanoi, 1999.Google Scholar
- Liu, Y., Hou, A. J., Ji, C. R., and Wu, Y. J., A new C-glycosidic hydrolyzable tannin from Rhodomyrtus tomentosa. Chin. Chem. Lett., 8, 39–40 (1997).Google Scholar
- Roodman, G. D., Advances in bone biology: the osteoclast. Endocrinol. Rev., 17, 308–332 (1996).Google Scholar