Archives of Pharmacal Research

, Volume 32, Issue 4, pp 465–480 | Cite as

Innovative vaccine production technologies: The evolution and value of vaccine production technologies

  • KyungDong BaeEmail author
  • JunYoul Choi
  • YangSuk Jang
  • SangJeom Ahn
  • ByungKi Hur


This review paper provides an overview of innovative technologies designed to produce bacterial, viral, recombinant subunit, and polysaccharide vaccines, as well as combination vaccines. Advances in this field are illustrated by vaccines against DTP (diphtheria-tetanus-pertussis), influenza, hepatitis B (HepB) and typhoid fever. In addition, technological trends regarding antigens, adjuvants, and preservatives in vaccines are discussed. The progress achieved in vaccine production technologies is especially important for improving the protection of vulnerable populations against infectious diseases. These at-risk groups include infants, the elderly and immunocompromized individuals, as well as people living in developing countries or emerging economies.

Key words

Vaccine Antigen Adjuvant CpG Virosome Ty21a 


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Copyright information

© The Pharmaceutical Society of Korea 2009

Authors and Affiliations

  • KyungDong Bae
    • 1
    Email author
  • JunYoul Choi
    • 1
  • YangSuk Jang
    • 1
  • SangJeom Ahn
    • 1
  • ByungKi Hur
    • 2
  1. 1.Vaccine Research InstituteCrucellBerna Biotech KoreaYonginKorea
  2. 2.Department of Biotechnology and BioengineeringInha UniversityIncheonKorea

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