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Archives of Pharmacal Research

, Volume 32, Issue 3, pp 431–436 | Cite as

Antitumor actions of imidazolyl-(4-oxoquinazolin-3(4H)-yl)-acetamides against Ehrlich Ascites Carcinoma

  • Nulgumnalli Manjunathaiah RaghavendraEmail author
  • Purvarga Mattada Gurubasavarajaswamy
  • Kanthappa Sathish Nagaranavile
  • Thampi Parameshwaran
Research Articles Drug Actions

Abstract

Breast cancer is the second most common type of cancer after lung cancer and the fifth most common cause of cancer death. Several structural classes of compounds were discovered against tumor, but many of the existing antitumor agents exhibit severe side effects. Hence there is a need to identify a novel chemical entity having a broad range of therapeutic activity with fewer side effects. In this direction, several imidazolyl-(4-oxoquinazolin-3(4H)-yl)-acetamides 1-4(a-d) were screened for their antitumor activity against Ehrlich Ascites Carcinoma (EAC) using in-vitro and in-vivo models. Compounds 4b, 4d, and 3a showed highly significant antitumor activity against EAC in comparison with vincristine as standard.

Key words

Quinazolin-4-ones Imidazolyl-(4-oxoquinazolin-3(4H)-yl)-acetamides Antitumor activity Ehrlich ascites carcinoma 

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Copyright information

© The Pharmaceutical Society of Korea 2009

Authors and Affiliations

  • Nulgumnalli Manjunathaiah Raghavendra
    • 1
    Email author
  • Purvarga Mattada Gurubasavarajaswamy
    • 1
  • Kanthappa Sathish Nagaranavile
    • 1
  • Thampi Parameshwaran
    • 1
  1. 1.Medicinal Chemistry Research LaboratoryAcharya and B.M. Reddy College of PharmacyBangaloreIndia

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