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Microbial metabolites of 8-prenylnaringenin, an estrogenic prenylflavanone

  • Hyun Jung Kim
  • So-Hyun Kim
  • Bok Yun Kang
  • Ik-Soo Lee
Research Article Drug Discovery

Abstract

Microbial metabolism studies of the phyto-estrogen (±)-8-prenylnaringenin (8-PN) (1) has led to the isolation of three pairs of metabolites (2–4). The structures of these compounds were identified as 5,4′-dihydroxy-7,8-[2-(1-hydroxy-1-methylethyl)-2,3-dihydrofurano]flavanones (2), 8-prenylnaringenin 7-O-β-D-glucopyranosides (3), and 8-prenylnaringenin 7-O-β-D-(6‴-O-α-hydroxypropionyl)-glucopyranosides (4) on the basis of the spectroscopic analysis.

Key words

Microbial metabolism 8-Prenylnaringenin 

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Copyright information

© The Pharmaceutical Society of Korea 2008

Authors and Affiliations

  • Hyun Jung Kim
    • 1
    • 2
  • So-Hyun Kim
    • 1
    • 3
  • Bok Yun Kang
    • 1
  • Ik-Soo Lee
    • 1
  1. 1.College of Pharmacy and Research Institute of Drug DevelopmentChonnam National UniversityGwangjuKorea
  2. 2.Department of MicrobiologyChonnam National University Medical SchoolGwangjuKorea
  3. 3.National Biobank of KoreaChonnam National University Hwasun HospitalJeonnamKorea

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