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Constituents of the flowers of Erigeron annuus with inhibitory activity on the formation of advanced glycation end products (AGEs) and aldose reductase

  • Dae Sik Jang
  • Nam Hee Yoo
  • Yun Mi Lee
  • Jeong Lim Yoo
  • Young Sook Kim
  • Jin Sook KimEmail author
Article

Abstract

Seven phenolic compounds, caffeic acid (1), 4-hydroxybenzoic acid (2), 4-methoxybenzoic acid (3), protocatechuic acid (4), eugenol O-β-D-glucopyranoside (5), 3,6-di-O-feruloylsucrose (6), and 3,5-di-O-caffeoylquinic acid methyl ester (7), were isolated from an EtOAc-soluble partition of the flowers of Erigeron annuus. The structures of 1–7 were determined by spectroscopic data interpretation, particularly 1D and 2D NMR studies, and by comparison of their data with those published in the literature. All the isolates were subjected to in vitro bioassays to evaluate their inhibitory activities against the formation of advanced glycation end products (AGEs) and rat lens aldose reductase (RLAR). Of the compounds, 1, 6, and 7 exhibited potent inhibitory activities against the formation of AGEs. In the RLAR assay, compound 7 showed the most potent inhibitory activity.

Key words

Erigeron annuus Compositae Phenolic compounds Advanced glycation end products (AGEs) Rat lens aldose reductase (RLAR) Diabetic complications 

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Copyright information

© The Pharmaceutical Society of Korea 2008

Authors and Affiliations

  • Dae Sik Jang
    • 1
  • Nam Hee Yoo
    • 1
  • Yun Mi Lee
    • 1
  • Jeong Lim Yoo
    • 1
  • Young Sook Kim
    • 1
  • Jin Sook Kim
    • 1
    Email author
  1. 1.Department of Herbal Pharmaceutical DevelopmentKorea Institute of Oriental MedicineDaejeonKorea

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