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Archives of Pharmacal Research

, Volume 31, Issue 7, pp 823–829 | Cite as

Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells

  • Phan Van Kiem
  • Tran Hong Quang
  • Tran Thu Huong
  • Le Thi Hong Nhung
  • Nguyen Xuan Cuong
  • Chau Van Minh
  • Eun Mi Choi
  • Young Ho Kim
Article

Abstract

A new coumaric acid derivative called acancifoliuside (1) and six known compounds as acteoside (2), isoacteoside (3), acanthaminoside (4), (+)-lyoniresinol 3a-O-β-glucopyranoside (5), (−)-lyoniresinol (6), and α-amyrin (7), were isolated from the methanolic extract of the leaves of Acanthus ilicifolius L. (Acanthaceae). Their structures were determined by spectroscopic methods and a comparison with the spectral data reported in the literature. The effects of the compounds on the function of osteoblastic MC3T3-E1 cells were tested. Compounds 2, 3, and 5 (30 μM) increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis.

Key words

Acanthus ilicifolius Acanthaceae Acancifoliuside Osteoblast 

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References

  1. Amer, M. E., Abou-Shoer, M. I., Abdel-Kader, M. S., El-Shaibany A. M. S., and Abdel-Salam, N. A., Alkaloids and flavone acyl glycosides from Acanthus arboreus. J. Braz. Chem. Soc., 15, 262–266 (2004).CrossRefGoogle Scholar
  2. Babu, B. H., Shylesh, B. S., and Padikkala, J., Antioxidant and hepatoprotective effect of Acanthus ilicifolius. Fitoterapia, 72, 272–277 (2001).PubMedCrossRefGoogle Scholar
  3. Babu, B. H., Shylesh, B. S., and Padikkala, J., Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius. J. Ethnopharmacol., 79, 27–33 (2002).PubMedCrossRefGoogle Scholar
  4. Bich, D. H., Trung, D. Q., Chuong, B. X., Dong, N. T., Dam, D. T., Hien, P. V., Lo, V. N., Mai, P. D., Man, P. K., Nhu, D. T., Tap, N., and Toan, T., The medicinal plants and animals of Vietnam. Hanoi Science and Technology Publisher, 1st edition, p. 497 (2004).Google Scholar
  5. Chi, V. V., The dictionary of Vietnamese medicinal plants. Hanoi Medicine Publisher, 1st edition, p. 886 (1999).Google Scholar
  6. Fang, H., Tong, W., Shi, M., Blair, R., Perkins, R., Branham, W., Hass, B. S., Xie, Q., Dial, S. L., Moland, C. L., and Sheehan, D. M., Structure activity relationships for a large diverse set of natural synthetic, and environmental estrogens. Chem. Res. Toxicol., 14, 280–294 (2001).PubMedCrossRefGoogle Scholar
  7. Kanchanapoom, T., Kamel, M. S., Kasai, R., Picheansoonthon, C., Hiraga, Y., and Yamasaki, K., Benzoxazinoid glucosides from Acanthus ilicifolius. Phytochemistry, 58, 637–640 (2001a).PubMedCrossRefGoogle Scholar
  8. Kanchanapoom, T., Kamel, M. S., Kasai, R., Yamasaki, K., Picheansoonthon, C., and Hiraga, Y., Lignan glucosides from Acanthus ilicifolius. Phytochemistry, 56, 369–372 (2001b).PubMedCrossRefGoogle Scholar
  9. Kapil, A. and Sharma, S., Leishmanicidal activity of 2-benzoxazolinone from Acanthus ilicifolius in vitro. Planta Med., 60, 187–188 (1994).PubMedCrossRefGoogle Scholar
  10. Kodama, H. A., Suda, Y., Kasai, H., and Yamamoto, S., Establishment of a clonal osteogenic cell line from newborn mouse calvaria. Jpn. J. Oral Biol., 23, 899–901 (1981).Google Scholar
  11. Minocha, P. K. and Tiwari, K. P., A triterpenoidal saponin from roots of Acanthus ilicifolius. Phytochemistry, 20, 135–137 (1981).CrossRefGoogle Scholar
  12. Miyase, T., Koizumi, A., Ueno, A., Noro, T., Kuroyanagi, M., Fukushima, S., Akiyama Y., and Takemoto, T., Studies on the acyl glycosides from Leucoseptrum japonicum (Miq.) Kitamura et Murata. Chem. Pharm. Bull., 30, 2732–2737 (1982).Google Scholar
  13. Ngounou, F. N., Lontsi, D., and Sondagam, B. L., A pentacyclic triterpene diacid from Myrianthus arboreus. Phytochemistry, 27, 2287–2289 (1988).CrossRefGoogle Scholar
  14. Ohashi, K., Watanabe, H., Okumura, Y., Uji, T., and Kitagawa, I., Indonesian medicinal plants. XII. Four isomeric lignanglucosides from the bark of Aegle marmelos. (Rutaceae), Chem. Pharm. Bull., 42, 1924–1926 (1994).Google Scholar
  15. Papoutsi, Z., Kassi, E., Mitakou, S., Aligiannis, N., Tsiapara, A., Chrousos, G., and Moutsatsou, P., Acteoside and martynoside exhibit estrogenic/antiestrogenic properties. J. Steroid Biochem. Mol. Biol., 98, 63–71 (2006).PubMedCrossRefGoogle Scholar
  16. Sasaki, H., Nishimura, H., Chin, M., and Mitsuhashi, H., Hydroxycinnamic acid esters of phenethylalcohol glycosides from Rehmannia glutinosa var. purpurea. Phytochemistry, 28, 875–879 (1989).CrossRefGoogle Scholar
  17. Tullberg-Reinert, H. and Jundt, G., In situ measurement of collagen synthesis by human bone cells with a Sirius Red-based colorimetric microassay: effects of transforming growth factor b2 and ascorbic acid 2-phosphate. Histochem. Cell Biol., 112, 271–276 (1999).PubMedCrossRefGoogle Scholar
  18. Wu, J., Zhang, S., Huang, J., Xiao, Q., Li Q., Long, L., and Huang, L., New alphatic alcohol and (Z)-4-coumaric acid glycosides from Acanthus ilicifolius. Chem. Pharm. Bull., 51, 1201–1203 (2003a).PubMedCrossRefGoogle Scholar
  19. Wu, J., Zhang, S., Xiao, Q., Li, Q. X., Huang, J. S., Long, L. J., and Huang, L. M., Phenylethanoid and aliphatic alcohol glycosides from Acanthus icilifolius. Phytochemistry, 63, 491–495 (2003b).PubMedGoogle Scholar
  20. Zhong, X., Otsuka, H., Ide, T., Hirata, E., Takushi A., and Takeda, Y., Hydroquinone glycosides from leaves of Myrsine seguinii. Phytochemistry, 49, 2149–2153 (1998).CrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 2008

Authors and Affiliations

  • Phan Van Kiem
    • 1
  • Tran Hong Quang
    • 1
  • Tran Thu Huong
    • 2
    • 1
  • Le Thi Hong Nhung
    • 2
    • 1
  • Nguyen Xuan Cuong
    • 1
  • Chau Van Minh
    • 1
  • Eun Mi Choi
    • 3
    • 1
  • Young Ho Kim
    • 3
    • 1
  1. 1.Institute of Natural Products ChemistryVietnamese Academy of Science and TechnologyNghiado, Caugiay, HanoiVietnam
  2. 2.Department of Chemical TechnologyHanoi University of TechnologyHai Ba Trung, HanoiVietnam
  3. 3.College of PharmacyChungnam National UniversityDaejeonKorea

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