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Archives of Pharmacal Research

, Volume 31, Issue 5, pp 569–572 | Cite as

New polyunsaturated fatty acid amides isolated from the seeds of Zanthoxylum piperitum

  • Kyoung Hwa Jang
  • Yong Ha Chang
  • Dae-Duk Kim
  • Ki-Bong Oh
  • Uhtaek OhEmail author
  • Jongheon ShinEmail author
Articles Drug Discovery

Abstract

Five linear fatty acid amides (1–5) of the sandshool class, including two new compounds, were isolated from Zanthoxylum piperitum seeds. Based on combined spectral analyses, the structures of new compounds 4 and 5 were determined to be 2′,3′-dihydroxy-α-sanshool and 2′,3′-dihydroxy-β-sanshool, respectively. These compounds exhibited weak cytotoxicity in the A-549 (human lung cancer) cell line.

Key words

Zanthoxylum piperitum Fatty acid amides Sanshools Dihydroxy-α-sanshool Dihydroxy-β-sanshool Cytotoxicity 

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Copyright information

© The Pharmaceutical Society of Korea 2008

Authors and Affiliations

  1. 1.College of PharmacySeoul National UniversitySeoulKorea
  2. 2.School of Agricultural BiotechnologySeoul National UniversitySeoulKorea
  3. 3.The Sensory Research Center, CRI, College of PharmacySeoul National UniversitySeoulKorea

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