Cytochrome P450 — vielseitige Enzyme für Medizin und Biotechnologie
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Cytochromes P450 are heme containing enzymes that catalyze numerous oxidation reactions including hydroxylation of non-activated CH-bonds, epoxidation, dealkylation and even C-C bond cleavage. Along with their broad substrate spectrum, P450s often possess high regio-, chemo-, and stereoselectivity, thereby playing an essential role in metabolism. Due to their versatility P450s are the rising stars in biotechnological applications and synthetic biology.
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- Schiffer L, Muller AR, Hobler A et al. (2016) Biotransformation of the mineralocorticoid receptor antagonists spironolactone and canrenone by human CYP11B1 and CYP11B2: characterization of the products and their influence on mineralocorticoid receptor transactivation. J Steroid Biochem Mol Biol 163:68–76CrossRefGoogle Scholar