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Das Rätsel der Sphinx — Mechanismen der zellulären Sphingolipidhomöostase

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Abstract

Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signalling molecules and as membrane components. They are important for many processes, including endocytic transport and plasma membrane integrity. Pathological changes in sphingolipid levels are associated with many common pathologies, ranging from obesity and cancer to neurodegenerative diseases and genetic disorders. Here we discuss the molecular mechanisms of cells to maintain sphingolipid homeostasis.

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Literatur

  1. Thudichum J (1884) A treatise on the chemical constitution of the brain. Bailliere Tindall and Cox, London

    Google Scholar 

  2. Platt FM (2014) Sphingolipid lysosomal storage disorders. Nature 510:68–75

    Article  CAS  Google Scholar 

  3. Olson DK, Fröhlich F, Farese RV Jr et al. (2015) Taming the sphinx: mechanisms of cellular sphingolipid homeostasis. Biochim Biophys Acta 1861:784–792

    Article  Google Scholar 

  4. Breslow DK, Collins SR, Bodenmiller B et al. (2010) Orm family proteins mediate sphingolipid homeostasis. Nature 463:1048–1053

    Article  CAS  Google Scholar 

  5. Berchtold D, Piccolis M, Chiaruttini N et al. (2012) Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol 14:542–547

    Article  CAS  Google Scholar 

  6. Roelants FM, Breslow DK, Muir A et al. (2011) Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 108:19222–19227

    Article  CAS  Google Scholar 

  7. Schmidt O, Weyer Y, Baumann V et al. (2019) Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism. EMBO J 38:e101433

    Article  Google Scholar 

  8. Olson DK, Fröhlich F, Christiano R et al. (2015) Rom2-dependent phosphorylation of Elo2 controls the abundance of very long-chain fatty acids. J Biol Chem 290

    Article  Google Scholar 

  9. Esch BM, Fröhlich F (2018) Mechanisms of Lipid Sorting in the Endosomal Pathway. In: Iglic A, Garcia-Saez A, Rappolt M (Hrsg) Advances in Biomembranes Lipid Self-Assembly, Academic Press, Cambridge

    Google Scholar 

  10. Fröhlich F, Petit C, Kory N et al. (2015) The GARP complex is required for cellular sphingolipid homeostasis. Elife 4, doi: 10.7554/eLife.08712

  11. Fröhlich F, Olson DK, Christiano R et al. (2016) Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion. Proteomics 16:2759–2763

    Article  Google Scholar 

  12. Eising S, Thiele L, Fröhlich F (2019) A systematic approach to identify recycling endocytic cargo depending on the GARP complex. Elife 8, doi: 10.7554/eLife.42837

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Authors and Affiliations

  1. Arbeitsgruppe Molekulare Membranbiologie, Fachbereich Biologie/Chemie, Universität Osnabrück, Barbarastraße 13, D-49076, Osnabrück, Deutschland

    Sergej Limar & Florian Fröhlich

Authors
  1. Sergej Limar
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  2. Florian Fröhlich
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Corresponding author

Correspondence to Florian Fröhlich.

Additional information

Sergej Limar Jahrgang 1990. Biologiestudium an der Universität Münster. Seit 2017 Doktorand an der Universität Osnabrück im Graduiertenkolleg „EvoCell“.

Florian Fröhlich Jahrgang 1981. Biologiestudium an der Universität Göttingen. 2010 Promotion. 2010–2015 Postdoc an der Yale Medical School, New Haven, USA, und der T. H. Chan Harvard School of Public Health, Boston, USA. Seit 2016 Nachwuchsgruppenleiter der Abteilung Molekulare Membranbiologie des SFB944 an der Universität Osnabrück.

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Limar, S., Fröhlich, F. Das Rätsel der Sphinx — Mechanismen der zellulären Sphingolipidhomöostase. Biospektrum 25, 704–706 (2019). https://doi.org/10.1007/s12268-019-1301-x

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  • DOI: https://doi.org/10.1007/s12268-019-1301-x

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