Abstract
Osteoporosis, the condition of decreased bone density resulting in bone porosity, brittleness, and a increased fracture risk is rising with aging. Current treatments slow-down bone loss but cannot increase bone formation and quality. Using osteoblasts–the bone forming cells–and RNAi libraries, we developed a high-content analysis approach which identified osteoblast modulators. Several among them are potential drug targets, to induce increase in bone formation thus efficiently combating osteoporosis.
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Torsten Kroll 1991–1997 Chemie-Studium an der Universität Jena und der University of Kent, Canterbury, UK. 1997–2004 Promotion zum Dr. rer. nat. am Hans-Knöll-Institut Jena und der Universität Jena. 2004–2012 Wissenschaftlicher Mitarbeiter am Universitätsklinikum Jena. 2012–2015 Forschungsingenieur am Leibniz Institut für Alternsforschung–Fritz-Lipmann- Institut (FLI) Jena. Seit 2016 Manager der Core Facility Functional Genomics am FLI Jena.
Aspasia Ploubidou 1993–1998 Promotion (Ph.D.) der Biologie an der University of Manchester, UK. 1998–2004 Postdoc-Aufenthalt am Europäischen Laboratorium für Molekularbiologie (EMBL), Heidelberg. Seit 2005 Gruppenleiterin am Leibniz Institut für Alternsforschung–Fritz Lipmann Institute, Jena. 2007–2015 Gründung und Leitung der Core Facility „Functional Genomics“ am FLI in Jena.
Mubashir Ahmad 2004–2009 Bachelor und Masterstudium der Biochemie. 2012–2018 Promotion zum Doktor der Naturwissen - schaften am Institut für Molekulare Endokrinologie der Tiere der Universität Ulm. Seit 2018 Postdoc am Institut für Molekulare Endo krinologie der Tiere der Universität Ulm
Jan Tuckermann 1989–1995 Diplom-Biologiestudium an der Universität Karlsruhe. 1996–1999 Promotion zum Doktor der Naturwissenschaften am Deutschen Krebsforschungszentrum und der Universität Karlsruhe. 1999–2004 Postdoc-Aufenthalt am Deutschen Krebsforschungszentrum Heidelberg. 2004–2012 Juniorgruppenleiter am Leibniz Institut für Alternsforschung–Fritz-Lipmann-Institut Jena. Seit 2012 W3-Universitätsprofessor für Zoologie und Endo - krinologie und Leiter des Instituts für Molekulare Endo - krinologie der Tiere, Universität Ulm.
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Kroll, T., Ahmad, M., Ploubidou, A. et al. RNAi-Screening in Knochenbildenden Zellen. Biospektrum 25, 523–526 (2019). https://doi.org/10.1007/s12268-019-1091-1
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DOI: https://doi.org/10.1007/s12268-019-1091-1