, Volume 25, Issue 1, pp 41–44 | Cite as

Das maßgeschneiderte Proteom: Proteinmodifikation durch Proteolyse

  • Fatih DemirEmail author
  • Andreas PerrarEmail author
  • Pitter F. HuesgenEmail author
Wissenschaft · Special: Proteinanalytik Proteomics


Site-specific proteolytic processing is an irreversible post-translational protein modification with essential regulatory functions. Dedicated methods enable proteome-wide characterization of differentially processed proteoforms based on their distinct protease-generated N termini. Exemplary profiling of murine glomeruli revealed processed forms of proteins with important functions in the renal filtration barrier. Altered processing was observed in cellular and animal models of glomerular disease.


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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2019

Authors and Affiliations

  1. 1.Zentralinstitut für Engineering, Elektronik und Analytik ZEA-3 AnalytikForschungszentrum Jülich GmbHJülichDeutschland
  2. 2.Medizinische Fakultät und Uniklinik KölnUniversität zu KölnKölnDeutschland

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