Schutzmechanismen der Gen-Umwelt-Achse in Morbus Parkinson
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Environmental factors harbor capacity to modulate onset and progression of Parkinson’s disease. To identify genes transducing beneficial environmental cues into the genomic program, we examined environment-induced changes in hippocampal gene activity of mice overexpressing human SNCA, an aetiological key gene. Our results point to an environment-inducible gene network that prevented SNCA-dependent disturbances in gene activity and might aid in identifying novel therapeutic opportunities.
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