, Volume 24, Issue 2, pp 146–148 | Cite as

Netzbildung als Abwehrstrategie des menschlichen Körpers

Wissenschaft Defensine


The human organism is protected against commensal and pathogenic microbes by antimicrobial molecules of the innate immune system. The human beta defensin 1 (hBD1) is one of the most prominent antimicrobial molecules and–in contrast to other defensins – constantly expressed by epithelial cells. A recent study displayed a new mechanism of hBD1: Besides bacterial cell envelope damage, it can form a so far unknown net-like structure. Bacteria can be entrapped in these nets providing a physical barrier which is independent of antimicrobial activity.


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  1. [1]
    Sender R, Fuchs S, Milo R (2016) Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 164:337–340CrossRefPubMedGoogle Scholar
  2. [2]
    Wehkamp J, Stange EF (2010) Paneth’s disease. J. Crohns Colitis 4:523–531CrossRefPubMedGoogle Scholar
  3. [3]
    Wilmes M, Cammue BPA, Sahl H-G et al. (2011) Antibiotic activities of host defense peptides: more to it than lipid bilayer perturbation. Nat Prod Rep 28:1350–1358CrossRefPubMedGoogle Scholar
  4. [4]
    Chu H, Pazgier M, Jung G et al. (2012) Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science 337:477–481CrossRefPubMedPubMedCentralGoogle Scholar
  5. [5]
    Schroeder BO, Ehmann D, Precht JC et al. (2014) Paneth cell a-defensin 6 (HD-6) is an antimicrobial peptide. Mucosal Immunol 8:661–671CrossRefPubMedPubMedCentralGoogle Scholar
  6. [6]
    Schroeder BO, Wu Z, Nuding S et al. (2011) Reduction of disulphide bonds unmasks potent antimicrobial activity of human ß-defensin 1. Nature 469:419–423CrossRefPubMedGoogle Scholar
  7. [7]
    Jaeger SU, Schroeder BO, Meyer-Hoffert U et al. (2013) Cell-mediated reduction of human ß-defensin 1: a major role for mucosal thioredoxin. Mucosal Immunol 6:1179–1190CrossRefPubMedPubMedCentralGoogle Scholar
  8. [8]
    Raschig J, Mailänder-Sánchez D, Berscheid A et al. (2017) Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action. PLOS Pathog 13:e1006261CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Innere Medizin 1Universitätsklinikum TübingenTübingenGermany
  2. 2.Abteilung Für Mikrobielle Wirkstoffe, Institut Für Mikrobiologie Und InfektionsmedizinUniversität TübingenTübingenGermany

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