Proteomik in kardiovaskulärer Forschung
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Cardiovascular diseases are the leading cause of death worldwide. The molecular mechanisms involved in the underlying pathophysiologies of atherosclerosis and heart related disorders are still poorly known. A closer understanding would greatly benefit clinical outcome predictions and treatment options in future. Two recent studies by Matthias Mann and his team, presented in this review, have addressed cardiovascular diseases using high-resolution mass spectrometry-based proteomics.
- Wierer M, Prestel M, Schiller H, Yan G, Schaab C, Azghandi S, Werner J, Kessler T, Malik R, Murgia M, Aherrahrou Z, Schunkert H, Dichgans M, Mann M (2018) Compartment-resolved proteomic analysis of mouse aorta during atherosclerotic plaque formation reveals osteoclastspecific protein expression. Mol Cell Proteomics 17:321–334CrossRefPubMedGoogle Scholar
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