Das RNA-Exosom – eine molekulare Maschine für den RNA-Abbau
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The exosome is an evolutionary conserved macromolecular complex that degrades RNAs from the 3′ end. It is present both in the cytoplasm and the nucleus, where it degrades different types of RNAs in yeast, human cells and other eukaryotes studied to date. The exosome is involved in the turnover of mRNAs, ncRNA and tRNAs, but also in the surveillance of faulty pre-mRNAs. In addition to its degradative function it is also involved in the controlled processing of e. g. rRNAs.
- Wasmuth EV, Zinder JC, Zattas D et al. (2017) Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Elife 6, doi: 10.7554/eLife.29062Google Scholar
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