Optische Genregulation in Mikrobioreaktoren
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Photolabile-caged effector molecules allow non-invasive regulation of gene expression using cell-compatible UVA-irradiation. Based on this method, independent photoregulation of gene expression was combined with optical online monitoring of important cultivation parameters in a 48-well plate format. Thereby, an innovative screening system was created which allows for cost-effective and easily automated expression profiling as well as closed-loop process control.
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