, Volume 23, Issue 1, pp 98–100

Hydantoinasen – von der präbiotischen Evolution zur Aminosäureproduktion

Biotechnologie Industrielle Enzyme

DOI: 10.1007/s12268-017-0770-z

Cite this article as:
Rudat, J. & Engel, U. Biospektrum (2017) 23: 98. doi:10.1007/s12268-017-0770-z


The hydantoinase process is used for the large-scale production of optically pure amino acids, with side chains of semisynthetic penicillins as the most prominent products. The origin as well as the natural function of the eponymous enzymes, however, remains unclear to this day. Here we discuss the way of hydantoinases from prebiotic evolution to directed evolution, spanning some billion years from the origin of life to industrial processes.

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Institut für Bio- und Lebensmitteltechnik Abteilung II: Technische BiologieKarlsruher Institut für Technologie (KIT)KarlsruheDeutschland

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